Eccles R (2010) Importance of placebo effect in cough clinical trials. Lung 188(Suppl 1):S53-61Eccles R: Importance of placebo effect in cough clinical trials. Lung 2010, 188 (Suppl 1):S53–S61.Eccles R (2010) Importance of placebo effect in cough clinical trials. Lung 188(Suppl 1):...
The point is that the placebo arm of a trial is particularly vulnerable to specific types of bias.In clinical trials, as opposed to regular patient care, patients are generally highly compliant and have a good feeling about the trial because they think it will provide something from which they...
In clinical pharmacological investigations placebos are used deliberately to discriminate the pharmacodynamic action of drugs from psychic and other factors which can influence the objective of the drug evalution. The use of placebo in therapeutic trials is justified only when no effective treatment is ...
Common placebo effects occur in medical trials when drugs are being tested. Sometimes, the subjects who receive the placebo instead of the drug believe they have the same results as if they did receive the drug. How does the placebo effect work?
The geriatric population is escalating globally, and the need for treating infectious and non-infectious diseases in elderly patients is also correspondingly increasing worldwide. In clinical trials and under doctor’s office settings, the drug dosages are generally computed on mg/kg body wt. basis...
augmenting the data available from the trial participant to bring to light broader trends. This data could also be utilized to minimize the number of patients receiving placebos as well as to better predict the expected placebo effect. These approaches should apply at b...
Alicia Morgans, MD:I completely agree with you, and I think that we all are familiar with Matthew Smith’s data published in theJournal of Clinical Oncologya number of years ago. It was a phase III clinical trial of denosumab for the prevention of metastatic disease in men with non...
Immunodepressed homosexuals at risk of developing acquired immunodeficiency syndrome (AIDS) treated with placebo or INPX experienced an increase in the function and number of immunocompetent cells associated with clinical improvement. A multicenter trial designed to confirm these results has demonstrated ...
One simple way to summarize the results of ABP monitoring in clinical trials is to provide the mean 24-hour BP difference from placebo and the BP decrease at trough. The numerous advantages summarized above make ABP monitoring an accepted method of BP measurement in hypertension therapy trials. ...
(RCT) encompassing a group of 12,200 patients treated with evolocumabe and alirocumab throughout the period of 12 weeks, a decrease in LDL concentration by 60.4% for evolocumabe administered every 2 weeks at a dose 140 mg in comparison with placebo was recorded. In the mentioned meta-...