Investigations of the effect of placebo are often challenging to conduct and interpret. The history of placebo shows that assessment of its clinical significance has a real potential to be biased. We analyze and discuss typical types of bias in studies on placebo. A methodological analysis and dis...
aThe placebo effect observed in this study (mean absolute change of 1.6 U [17.6%]) is consistent with reports of placebo effects in previous studies of rhinitis and olopatadine. 在这项研究观察的安慰剂作用(卑鄙绝对变动中的1.6 U (17.6%))与安慰剂作用报告是一致的在鼻炎和olopatadine的早先研究中。
Walach H, Schneider R (2009) Does the presence of a pharmacological substance alter the placebo effect? – results of two experimental studies using the placebo-caffeine paradigm. Hum Psychopharmacol 24(7):549–558. : 10.1002/hup.1054Walach H, Schneider R. Does the presence of a ...
Randomized, double-blind, placebo-controlled, parallel group clinical trials have been the standard methodology for establishing the efficacy of new treatments for patients with bipolar disorder in manic, mixed, or depressive episodes. We examine the placebo response rate in acute treatment trials of ...
The prevention of mood episodes is an important goal of the maintenance treatment of patients with bipolar disorder. The rate of relapse on placebo compared with that on active treatment is an important issue in the design of future clinical trials of maintenance treatment. We examine the range ...
There is a rich literature on the role of placebos in experimental design and evaluation of therapeutic agents or interventions. The importance of masking ... F Jamshidian,AE Hubbard,NP Jewell - 《Statistical Methods in Medical Research》 被引量: 23发表: 2011年 Informed consent: What informatio...
polydextrose ingestion on clinical biochemistry indexes, glycated hemoglobin, glucose tolerance, the glycemic index, bowel function, stool weight and pH, short-chain fatty acid production, fecal microflora, and cecal mucosa cell proliferation.Polydextrose had no significant effect on blood biochemistry ...
their younger counterparts. Another interesting discovery was the effect of prescribed pain medications on score improvements. Researchers found that participants who were continuously prescribed at least one pain medication (including opioids) were 2.46x less likely to achieve clinically significant results....
Why is the bystander effect important? What is an example of the bystander effect? What event started research on the bystander effect? What causes the bystander effect? How does the bystander effect groups? Why the bystander effect happens? What issues are involved in allowing ...
These findings may indicate that SFI exerted a better protective effect, especially in the early stage, while SMI was better in the chronic stage. Figure 1 Cardiac protective effects of SFI and SMI on eNOS KO mice with echocardiography performed on days 0, 3, 7, and 14. (A) LVEF assay....