Atrial remodeling in diabetes is partially attributed to NF-κB/TGF-β signal transduction pathway activation. We examined whether the hyperglycemia-induced increased expression of NF-κB/TGF-β was dependent upon protein kinase C-β (PKCβ) and tested the hypothesis that selective inhibition of PKC...
[3]WangX,YuW,NawazA,eta1.Palmitateinducedinsulinresistnace increasesresistanceofC57BL/6Jmicetoplasmodium bergheiinfee— byPKCtheta—dependentactivation ofmTOR/S6K pathway inC2C12 tion—inducedcerebralmalaria[J].InfectImmun,2010,78(1O): myotubes[J].ExpClinEndoerinolDiabetes,2010,118(9):657— 4195...
安徽医蚪大学硕士学位论文 PKC抑制剂灯盏花素对糖尿病大鼠肾脏 保护作用机制的实验研究 研究生 林辉 导师 吴永贵教授 中文摘要 背景与目的糖尿病肾病(Diabeticnephropathy,DN)早期特征性病理改变为l肾 脏肥大、细胞外基质(Extracellularmatrix,ECM)聚集和基底膜增厚,逐渐发展 为肾小球硬化,最终导致终末期肾病(End—stage...
Compensation of the pancreatic β cell functional mass in response to metabolic stress is key to the pathogenesis of Type 2 Diabetes. The mTORC2 pathway governs fuel metabolism and β cell functional mass. It is unknown whether mTORC2 is required for regulating metabolic stress-induced β cell co...
(all P less then 0.001), correspondingly. These associations with waistline circumference were better quality than with BMI. Conclusions Adults not diagnosed with diabetes with irregular BMI or waist circumference would be the key population for prevention and control. Steps enhancing the awareness rate...
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–protein kinase C (PKC) pathway plays an important role in...
Tanshinone IIA pretreatment protects myocardium against ischaemia/ reperfusion injury through the phosphatidylinositol 3- kinase/Akt-dependent pathway in diabetic rats [J]. Diabetes Obes Metab, 2010, 12(4): 316-322. [9] 王松, 汪茂胜, 周定荣, 等 . 丹参酮ⅡA 聚乙二醇-聚己内 酯纳米胶束的制备,...
PKC Inhibition Improves Human Penile Vascular Function and the NO/cGMP Pathway in Diabetic Erectile Dysfunction: The Role of NADPH Oxidase doi:10.3390/ijms25063111SILDENAFILIMPOTENCECOFACTORS (Biochemistry)PEOPLE with diabetesPHOSPHODIESTERASE inhibitorsENDOTHELIUM diseasesPENILE prosthesesErectile...
(ANOVA) and student t-tests to investigate gender and ethnicity differences in caries experiences. Simple chi-square tests were used to investigate gender and ethnicityCilengitidedifferences in each of the possible diseases (asthma, epilepsy, diabetes, cardiovascular disease (CVD), infections, medication...
暡关键词暢 暋 糖尿病心肌病; 暋 信号通路; 暋PKC 毬 2 ; 暋JNK1 ; 暋IRS1 暡中图分类号暢 暋R329暋暋 暡文献标识码暢 暋A暋暋 暋暋DOI : 10灡3870 / zgzzhx灡2014灡01灡009 InterventionofDAG灢PKCpathwayaffects JNK1andIRS1expressionindiabeticratmyocardium WangShengji 1* , WuWei 1* , FanXi...