Nephrin, is the major component of the glomerular slit diaphragm and loss of nephrin has been well described in rodent models of experimental diabetes as well as in human diabetic nephropathy.In this manuscript we analyzed the role of PKC-alpha (PKCalpha) on endocytosis of nephrin in podocytes....
As expected, Klotho deficiency aggravated diabetes-induced proteinuria and podocyte injury, accompanied by the activation of PKC alpha and p66SHC. In contrast, overexpression of Klotho partially ameliorated PKC alpha/p66SHC-mediated podocyte injury and proteinuria. In addition, in vitro experiments ...
In diabetes, hyperglycemia leads to the loss of surface expression of nephrin and causes albuminuria. Here, we report a mechanism that can explain this phenomenon: hyperglycemia directly enhances the rate of nephrin endocytosis via regulation of the beta-arrestin2-nephrin interaction by PKCalpha. We...
The S100B protein is a small acidic metal binding protein that has been found to be associated with neurological disorders and traumas, diabetes, and cancer. This work examines Zn2+ regulation of S100B Ca 2+-binding affinity and target protein interaction and also explores S100B interaction and...
As expected, Klotho deficiency aggravated diabetes-induced proteinuria and podocyte injury, accompanied by the activation of PKC alpha and p66SHC. In contrast, overexpression of Klotho partially ameliorated PKC alpha/p66SHC-mediated podocyte injury and proteinuria. In addition, in vitro experiments ...
Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na+-K+-ATPase alpha1-subunit in rats. AIMS/HYPOTHESIS: C-peptide reduces renal damage in diabetic patients and experimental animal models. In vitro studies suggest that the renal effects of C-p... L Nordquist,K Shimada,...
Exposure of MCs to AOPPs, through membrane-associated phosphorylation of PKCalpha, induced rapid phosphorylation of cytosolic p47(phox) and its membrane translocation, enhanced interaction of p47(phox) with the membrane components p22(phox) and Nox4, and increased expression of these key regulatory ...
The role of protein kinase C activation and the vascular complications of diabetes. Diabetes mellitus is a chronic disease caused by inherited and/or acquired deficiency in production of insulin by the pancreas, and by resistance to insuli... ND Evcimen,GL King - 《Pharmacological Research》 被引...
T Babazono,J Kapor-Drezgic,JA Dlugosz - 《Diabetes》 被引量: 238发表: 1998年 Prevention of glomerular dysfunction in diabetic rats by treatment with d-alpha-tocopherol. Because d-alpha-tocopherol (vitamin E) has been shown to decrease diacylglycerol (DAG) levels and prevent the activation of...
Osicka TM, Russo LM, Qiu ML, Brammar GC, Thallas V, Forbes JM, Comper WD, and Jerums G. Additive effects of hypertension and diabetes on renal cortical expression of PKC alpha and epsilon and alpha tubulin but not PKC beta 1 and beta 2. J Hypertens 21: 2399 -2407, 2003...