- 《Diabetes》 被引量: 0发表: 2007年 Effect of Ruboxistaurin on Visual Loss in Patients with Diabetic Retinopathy To evaluate the effect of ruboxistaurin, an orally administered protein kinase C beta (PKC beta) isozyme-selective inhibitor, on vision loss in patients wi... LP Aiello,MD Davis,...
Atrial remodeling in diabetes is partially attributed to NF-kappa B/TGF-beta signal transduction pathway activation. We examined whether the hyperglycemia-induced increased expression of NF-kappa B/TGF-beta was dependent upon protein kinase C-beta (PKC beta) and tested the hypothesis that selective ...
Osicka TM, Russo LM, Qiu ML, Brammar GC, Thallas V, Forbes JM, Comper WD, and Jerums G. Additive effects of hypertension and diabetes on renal cortical expression of PKC alpha and epsilon and alpha tubulin but not PKC beta 1 and beta 2. J Hypertens 21: 2399 -2407, 2003...
Diabetes mellitus, known for its complications, especially vascular complications, is becoming a globally serious social problem. Atherosclerosis has been recognized as a common vascular complication mechanism in diabetes. The diacylglycerol (DAG)–prote
中文名称:磷酸化蛋白激酶C β1/β2(Thr500)抗体 英文名称:Anti-phospho-PKC beta 1/2(Thr500)别名:MGC41878; PKC B; PKC beta; PKCB; PKCB1; PKCB2; PKCbeta; PRKCB 1; PRKCB 2; PRKCB; PRKCB I; 包装号:G320 产地:中国大陆/进口产品 商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology...
Beta-- Data delayed at least 15 minutes, as of Nov 08 2024 20:52 GMT. Find More Stocks Use our equities screener to discover other potential opportunities. Go to the Equities Screener Your alerts About the company Novo Nordisk A/S is a global healthcare company engaged in diabetes care. ...
Munc13–1 is required for the sustained release of insulin from pancreatic beta cells. Cell Metab. 3, 463–468 (2006). Article CAS PubMed Google Scholar Kwan, E.P. et al. Munc13–1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes 55, 1421–1429 (2006...
transcriptional regulation and tumor promotion. PKC beta has been implicated in diabetes and carcinogenesis. PKC beta isoforms 1 & 2 are phosphorylated on three sites, threonine 500 in the activation loop, beta 1 threonine 642 (beta 2 641) in the turn loop and beta 1 serine 661 (beta 2 66...
Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets[J]. J?Cell?Sci, 2000,113(18):3187-3196. 返回引文位置Google Scholar 百度学术 万方数据 [25] Wei L , Sun D , Yin Z ,et al. A PKC-beta inhibitor...
These data suggest that increased levels of SGLT1 may enhance glucose uptake in ER cells. Indeed, treatments with SGLT inhibitors phlorizin and LX4211 (sotagliflozin, approved in the European Union for type 1 diabetes mellitus) reduced the 2-NBDG uptake in H322/ER and HCC827/ER clones under...