Cell Metab, 2024, S1550-4131(24)00371-1 Nucleic Acids Res, 2024, gkae322 Clin Transl Med, 2024, 14(5):e1660 S7119Go6976Go6976 (PD406976)是一种强效的PKC抑制剂,其对PKC (老鼠大脑), PKCα, and PKCβ1的IC50分别为7.9nM,2.3 nM, 和 6.2 nM 。此外,也是JAK2和Flt3的强抑制剂。
Osicka TM, Russo LM, Qiu ML, Brammar GC, Thallas V, Forbes JM, Comper WD, and Jerums G. Additive effects of hypertension and diabetes on renal cortical expression of PKC alpha and epsilon and alpha tubulin but not PKC beta 1 and beta 2. J Hypertens 21: 2399 -2407, 2003...
Atrial remodeling in diabetes is partially attributed to NF-kappa B/TGF-beta signal transduction pathway activation. We examined whether the hyperglycemia-induced increased expression of NF-kappa B/TGF-beta was dependent upon protein kinase C-beta (PKC beta) and tested the hypothesis that selective ...
中文名称:磷酸化蛋白激酶C β1/β2(Thr500)抗体 英文名称:Anti-phospho-PKC beta 1/2(Thr500)别名:MGC41878; PKC B; PKC beta; PKCB; PKCB1; PKCB2; PKCbeta; PRKCB 1; PRKCB 2; PRKCB; PRKCB I; 包装号:G320 产地:中国大陆/进口产品 商标/品牌:Santa、Abcam、MBL、BD、Cell Signaling Technology...
in diabetic atherosclerosis. fig. 1 pkcδ, cd31,α-sma, and cd68 staining in a femoral artery tissue from lower limb of a 60years diabetes patient who had underwent an amputation surgery ( a , b ). representative images of he staining of vessels. c positive co-staining of cd31/pkcδ ...
Protein kinase C activation leads to dephosphorylation of occludin and tight junction permeability increase in LLC-PK1 epithelial cell sheets[J]. J?Cell?Sci, 2000,113(18):3187-3196. 返回引文位置Google Scholar 百度学术 万方数据 [25] Wei L , Sun D , Yin Z ,et al. A PKC-beta inhibitor...
” Demographic characteristics for AIDS-KS clients within our cohort match established styles in this subtype, such as for example male, MSM, and more youthful age at analysis when compared with HIV-negative customers. Most Unclassified-KS-Type patients fit really into the rising “non-epidemic ...
G.G. Holz, Epac: A new cAMP-binding protein in support of glucagon-like peptide-1 receptor-mediated signal transduction in the pancreatic beta-cell. Diabetes 53, 5–13 (2004)PubMedCentralCrossRefPubMed 7. K. Ban, M.H. Noyan-Ashraf, J. Hoefer, S.S. Bolz, D.J. Drucker, M. Husai...
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Munc13–1 is required for the sustained release of insulin from pancreatic beta cells. Cell Metab. 3, 463–468 (2006). Article CAS PubMed Google Scholar Kwan, E.P. et al. Munc13–1 deficiency reduces insulin secretion and causes abnormal glucose tolerance. Diabetes 55, 1421–1429 (2006...