pKa vs pH Relationship pH and pKa are two important values used when talking about acid-base chemistry and it can be hard to distinguish the two. pH is the negative log of the concentration of hydrogen ions in a solution, {eq}pH=-log[H^+] {/eq}. The pH of a system is a value ...
cAMP not only elicits intracellular signaling transduction, but also releases into extracellular space and the bloodstream. The ABCC transporter family members ABCC4/5/11 mediate the export of cAMP to extracellular space [29]. In turn, the extracellular cAMP is converted into adenosine by ectonucleot...
(89a), analkyl groupin the 5-position unexpectedly lowers the pKavalue by about 0.60 unit, presumably for thermodynamic reasons. Comparison of 5- and 4(hydroxyphenyl) DTTs (e.g.98and3b) shows similarly the lower acidity of the latter (98J(P2)2227), obviously because of a weaker ...
with an initial RMSE of 1.77 pKa units (ryzue) that could be improved to 1.40 by including a standard state correction and a different value for the free energy of the proton, the authors also showed the effectiveness of a simple linear regression scheme to correct the raw acidity constants...
This presentation reports some novel extensions and applications of the COSMO-RS methodology towards the prediction of acidity and basicity pKa of solutes in non-aqueous solvents such as acetonitrile, dimethylsulfoxide (DMSO), 1,2-dimethoxyethane (DME) and heptane. Correlating the quantum chemical ...
According to the plot absorbance at 291 nm versus pH it was possible to determine one pKa value for CEPA (5.13 ± 0.01), which can be associated to the pyridinium group (pKa2) located at the R1 substituent of this drug. Between the pH range 1.5–7 the observed titration curve exhibited...
with an initial RMSE of 1.77 pKa units (ryzue) that could be improved to 1.40 by including a standard state cor- rection and a different value for the free energy of the proton, the authors also showed the effectiveness of a simple linear regression scheme to correct the raw acidity consta...