(89a), analkyl groupin the 5-position unexpectedly lowers the pKavalue by about 0.60 unit, presumably for thermodynamic reasons. Comparison of 5- and 4(hydroxyphenyl) DTTs (e.g.98and3b) shows similarly the lower acidity of the latter (98J(P2)2227), obviously because of a weaker ...
inhibitors increases intracellular cAMP levels but suppresses cell cycle progression and survival [112]. PDE4D depletion also inhibits the expression of cancer-related genes such as IGF2 and the progression of cell cycle in HCC cells [113]. Together, these studies indicate that cAMP has opposing e...
Acidity constant of a weak acid.The partial dissociation of acid upon dissolution in the solvent is the major characteristics of a weak acid. pKa of acids defines the acidic strength in a given solution. It is a quantitative measurement.
Only one value was determined experimentally for CEF (2.68 ± 0.05), which was associated to the carboxylic acid group deprotonation. For CEPA two values were obtained experimentally: 2.74 ± 0.01 for the carboxylic acid deprotonation and 5.13 ± 0.01 for the pyridinium ring deprotonation. In ...
pka Table - pKa is an acid dissociation constant used to describe the acidity of a particular molecule. Its value is directly related to the structure of the given compound.