K. (1995) Abnormally high pKa of an active- site glutamic acid residue in Bacillus circulans xylanase. The role of electrostatic interactions, FEBS J. 232, 839-843.Davoodi, J., W. W. Wakarchuk, R. L. Campbell, P. R. Carey, and W. K. Surewicz. 1995. Abnormally high pKa of an...
[44] Ma SR, Yu JB, Fu J, et al. Determination and application of nineteen monoamines in the gut microbiota targeting phenylalanine, tryptophan, and glutamic acid metabolic pathways. Molecules. 2021;26(5):1377. [45] Lai F, Jiang R, Xie W, et al. Intestinal pathology and gut microbiota ...
[44] Ma SR, Yu JB, Fu J, et al. Determination and application of nineteen monoamines in the gut microbiota targeting phenylalanine, tryptophan, and glutamic acid metabolic pathways. Molecules. 2021;26(5):1377. [45] Lai F, Jiang R, Xie W, et al. Intestinal pathology and gut microbiota ...
Calculate the dissociation constant, K_a, of glutamic acid with C = 0.100 mol/L and pH = 1.585. Calculate the pH of a solution containing 0.4 M of butanoic acid (CH3CH2CH2COOH) and 1.2 M of potassium butanoate (K+CH3CH2CH2COO-). The pKa of butanoic acid is 4.82. ...
Zaro 等[14]设计了一种pH 响应组氨酸-谷氨酸(histidine–glutamic acid, HE)重复序列,并将其与一种CPP 融合,得到重组多肽(histidine-glutamic acid-cell penetrating peptide, HE-CPP)。研究发现,与pH 7.4 相比,HE-CPP 被HeLa 细胞摄取量显著低于pH 6.8,证实了HE 重复序列的pH 敏感性。这是因为在正常生理条件...
The structure of glutamic acid in the stomach is shown below. The group contains a carboxylic acid group and pKa (α-COOH) = 2.10, pKa (α-NH3+) = 9.47 and pKa (side-chain) = 4.07. As stomach pH is lower than each of these values, each of the...
This motif is characteristic of basophilic kinases including PKA. There are also prominent acidic amino acids (aspartic acid [D] and glutamic acid [E]) suggesting that H89 may inhibit one or more acidophilic kinases e.g., casein kinases, indirectly downstream from PKA. Interestingly, in ...
Intermedin inhibits vascular calcification by increasing the level of matrix gamma-carboxyglutamic acid protein. Cardiovasc Res 2010; 85: 864–73. Article CAS PubMed Google Scholar Okamoto H . Osteopontin and cardiovascular system. Mol Cell Biochem 2007; 300: 1–7. Article CAS PubMed Google ...
To selectively impair the VASP–Pfn1 interaction without causing any major structural perturbation of VASP, we set out an initial strategy to introduce a glutamic acid substitution on the third proline residue in each of the first four GP5 clusters and Leu209 in the last PLP segment in a ...
δ (pH 7) 2.06 24.5 177.8 8.33 3.95 45.4 174.6 114.6 8.38 4.61 2.70 54.3 41.1 180.3 176.9 120.2 8.47 3.90 45.2 177.3 110.8 7.10 7.53 107.6 3 Table S1 - con't residue acetyl Gly(- 1) Glu Gly(+1) amide nucleus type nucleus δ (HA) δΔδ (A) (A - HA) Glutamic aci...