(pKa). The equilibrium constant for the dissociation of an acid into its conjugate base and hydrogen ion, expressed as the negative logarithm. The lower the pKa of a sulphydryl group, the greater the likelihood that the sulphur will be anionic at ambient pH. Chronic granulomatous disease (CGD...
THE DETERMINATION OF THE pKa OF A WEAK ACID AND ITS CONTENT IN AN UNKNOWN - Modern Experimental Chemistry - 6ELSEVIERModern Experimental Chemistry
This simple relation is not strictly exact, however, as the buffering effect of the weak acids formed by dissolution of silicon and boron species during glass alteration must be taken into account: each mole of weak acid neutralizes one mole of strong base (Eqs. (2)–(6)) [104]. Some ...
4.5.Which of the following statements about an aqueous solution of HA is true? At pH=4.5,the solution contains moreH-A thanA- AtpH=4.5,the solution contains moreA-thanH-A At pH=3.5,the solution contains lessA-than HA AtpH...
If an amide group is protonated, it will be at the oxygen rather than the nitrogen. Exercises 1. a) Draw the Lewis structure of nitric acid, HNO3. b) Nitric acid is a strong acid – it has a pKaof -1.4. Make a structural argument to account for its strength. Your answer should in...
3j, k). Taken together, these data suggest that optogenetic regulation of parathyroid cells can reversibly increase intracellular calcium levels in addition to inhibiting the secretion of human PTH through the PKA/cAMP and PLA2-arachidonic acid (AA) signaling pathways. To further study whether light...
英文别名: ansornitinib;1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- 中文名: 化合物 ANSORNITINIB 中文别名: 安索替尼;化合物 ANSORNITINIB CBNumber: CB21...
产品介绍: 中文名称:化合物 ANSORNITINIB 英文名称:1H-Pyrrolo[2,3-b]pyridine-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[2-(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester, (3Z)- CAS:1448874-96-1 纯度:95%,98% 包装信息:5G...
Although it is less lipid soluble than fentanyl because of its low pKa (negative logarithm of the acid ionization constant), a higher percentage of the drug is present in the active unionized form, which results in a rapid onset. Because of its low volume of distribution, alfentanil has a ...
Repaglinide, the anti-diabetic drug for kidney-impaired patients, was also formulated as SNEDDS to enhance its low water-solubility, low absorption, and low (56%) bioavailability. Various oils were used which included oleic acid, isopropyl myristate IPM, Labrafil 1944, and 2125 together with chro...