而且强酸性的pKa比强碱性的pKa要大。比如1-甲基鸟苷的两个pKa分别是12.45 和1.9…对于一个含有多个...
而且强酸性的pKa比强碱性的pKa要大。比如1-甲基鸟苷的两个pKa分别是12.45 和1.9…水溶液中H+离子...
我想要查化合物的pKa值，譬如普罗帕酮，在Scifinder 上查到pka acidic=13.82, pKa bisic=9.31,...
Acidic Introduction to pH - the acidic and basic (alkaline) definition. pH can be viewed as an abbreviation for power of Hydrogen - or more completely, power of the concentration of the Hydrogen ionin a liquid. The mathematical definition of pH is a bit less intuitive but in general ...
Three pK(a) values were obtained: an acidic pK(a1) = 8.84 and two basic, pK(a2) = 4.15 and pK(a3) = 1.33. These pK(a) values were discussed from the point of lansoprazole structure and instability with the aim of locating basic and acidic moieties in the molecule of proton pump ...
(Fig.2).2,6,8More than 60 acid hydrolases, including proteases, lipases, nucleases, have been found within the lysosome, and they require an acidic (pH ~4.5) environment maintained by the cooperation of an ATP-driven proton pump called the vacuolar H + -adenosine triphosphatase (v-...
NMR is an excellent tool for monitoring the impact of co-solvent effects on pKa and buffering capacity of basic monomers because chemical shift is extremely sensitive to small changes that most other methods cannot detect. Because lactic acid (LA) is produced by oral bacteria and is prevalent ...
The myelin sheath of the nervous system provides trophic and metabolic support to underlying axons and facilitates faster action potential transmission by saltatory conduction. In the mammalian central nervous system, the classic isoforms of myelin basic
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In addition, basic and acidic drugs exhibit pH-dependent solubility profiles varying by more than 2 orders of magnitude in the physiological pH range. Of these, the most difficult drugs to formulate are weakly basic compounds which are practically insoluble at pH >5 (e.g., have a solubility ...