Determination of the pKa of alpha-Hydrogens in Cyclobutanone by Deuterium Incorporation StudiesSteve M. Cope
Understanding pKa values is crucial in organic chemistry, as they indicate the strength of acids.Alkaneshave the highest pKa (~50), making them the weakest acids, whilealkynesare stronger with a pKa of 25. Alpha hydrogens near carbonyls have a significantly lower pKa of 20 due to tautomerizati...
Role of hydrophobic interactions and desolvation in determining the structural properties of a model alpha beta peptide. exhibited large pKa shifts of several ionizable groups and slow hydrogen/deuterium exchange rates of nearly all the peptide amide groups [Butcher, D. J... D J,Butcher,G R,....
(a) Hydrogen peroxide (HOOH) has a pKa of 11.6, making it roughly 10,000 times as strong an acid as water (pKa = 15.7). Explain why H2O2 is a stronger acid than H2O. Verified Solution This video solution was recommended by our tutors as helpful ...
CORINA descriptors used in the modeling procedure, a correlation was established between biodegradability and properties including solubility, atomic charges, the number of rotatable bonds, lone pair/atomic electronegativity, molecular weight, and the number of nitrogen-atom-based hydrogen bond acceptors. ...
Tsa1 is also known to downregulate the cAMP/protein kinase A (PKA) pathway as part of the response to hydrogen peroxide stress. However, whether the cAMP/PKA pathway is involved in protein misfolding stress is not known. Using transcriptomics, we examined the response to protein misfolding ...
The structural determinants of the unusually low pK(a) values of Cys282 in human creatine kinase and Cys232 in alpha1-antitrypsin were studied computationally. We have demonstrated that hydrogen bonding to the cysteine residue is the prime determinant for both proteins. In the case of creatine ki...
reagent for metal-halogen exchange; metallation of active hydrogen compds., 1,3-pentadiyne, allene; with kobut, allylic metallation of alkenes; elimination of acetals to give alkenes; directed metallation of arenes, aryl ethers, methylated pyridines and quinolines; effects 2,3-wittig ...
described The results of the HA(CA)N experiment are shown in Fig. 1a, and although the primary purpose of this experiment was to detect the 15N chemical shift of the terminal nitrogen, the alpha hydrogen clearly also shows a pH dependence that is strongly correlated to that of the 15N....
R. Evidence for Chilling-Induced Oxidative Stress in Maize Seedlings and a Regulatory Role for Hydrogen Peroxide. Plant Cell 6, 65–74 (1994). Article CAS PubMed PubMed Central Google Scholar Cannon, B. & Nedergaard, J. Brown adipose tissue: function and physiological significance. Physiol ...