软硬酸碱理论 简称HSAB(Hard-Soft Acid and Base)理论,由Pearson提出,其将酸、碱分为硬、软两种。硬酸是指那些体积小、正电荷高、束缚外层电子更为牢固的粒子,反之为软酸。软碱是指那些体积大、电负性低、外层电子更为松散的粒子,反之为硬碱。 同等条件下,软酸易与软碱反应,而硬酸易与硬碱反应。即“软亲...
酸碱反应-3-Acid Base Strength - 酸碱强度_ 11:39 酸碱反应-4- Net Ionic Equations 反应离子式 13:33 酸碱反应-5-How To Calculate The pH of a Solution PH的计算 21:09 酸碱反应-6-pH of Weak Acids and Bases - Percent Ionization - 弱酸弱碱的PH+解离比计算 29:31 酸碱反应-7-pH, pOH...
Previdello, B. A. F.; de Carvalho, F. R.; Tessaro, A. L.; de Souza, V. R.; Hioka, N. The pK(a) of acid-base indicators and the influence of colloidal systems., Quimica Nova 2006, 29, 600-606.Previdello BAF, Carvalho FRD, Tessaro AL, Souza VRD, Hioka N (2006) The ...
pH and pKa are two important values used when talking about acid-base chemistry and it can be hard to distinguish the two. pH is the negative log of the concentration of hydrogen ions in a solution, pH=−log[H+]. The pH of a system is a value that is measured and can change depe...
25Acid pKa 353738BuLi Base pKa (of conj. acid)4045-52 RMgBr PhLi Acid pKa NaH/KH R 2NLi NH 2-CH 3SOCH 2-Na +Ph 3C -N N (CH 2)n tBuO -EtO -MeO -N NMe 2 HO -Na 2CO 3 45454035~37363531191811-13 171612 10-12PhO -R 3N ImH NaHCO 3PhNEt 2pyridine AcO -710107655...
If you're working with acids and bases,pH and pKaare two values you should be familiar with. Below is the definition of pKa and a look at how it relates to acid strength. pKa Definition pKais the negative base-10 logarithm of theacid dissociation constant(Ka) of asolution. ...
[1]: Manallack, D. T.; Prankerd, R. J.; Yuriev, E.; Oprea, T. I.; Chalmers, D. K. The significance of acid/base properties in drug discovery. Chem. Soc. Rev.2013, 42 (2), 485– 496. [2]: De Oliveira, C.; Yu, H. S.; Chen, W.; Abel, R.; Wang, L. Rigorous ...
1. The ADME properties include solubility,pKa(acid-base dissociation constant),Human intestinal absorption(HIA) and the human oral bioavailability. 这些性质包括水溶解度、酸碱离解常数(pKa)、药物的肠吸收(HIA)性质和药物的生物利用度。2) pKa values 酸碱解离常数 1. Two quantitative models for the ...
Predicting the Strength of Bases So far, we have talked about the strength of the acid. However, it is also very important to understand the strength of the base. Let’s look at the dissociation of ethanol and ethyl amine one more time: We have determined that ethanol is a stronger acid...
The hard-soft acid-base principle Although the strengths of acids andbases can be adequately described via the relative pKa and pKb values,respectively, within the Lowry–Bronsted acid–... RG Pearson,PK Chattaraj - 《Chemtracts》 被引量: 5发表: 2008年 取代酚酸性PKa和取代苯胺碱PKb的分子拓扑...