We further identified cAMP-responsive element protein 1 (CREB1), a transcription factor and a substrate of PKA, as a key regulator of ferroptosis. Knockdown of CREB1 sensitized NSCLC cells to ferroptosis inducers (FINs) and abolished the effects of PKA inhibitor and agonist, revealing the pivotal...
图6. CREB引导糖异生基因的H3S28磷酸化。 (A) 经对照组和Creb1-sgrna处理的动物的肝蛋白WB分析。 (B) 小鼠肝脏核蛋白中PKA-Cα和H3的内源性免疫共沉淀。 (C) PKA-cα结合序列的基序分析。 (D) 指示动物肝脏PKA-Cα的CUT...
Overexpression of CREB1 and EPAC1 is also associated with gastric cancer progression [100,101]. In addition, DARPP-32 activates IGF1R and STAT3 signaling in gastric cancer cells [102]. NF-κB activation and hypermethylation-mediated silencing of miR490-3p byH. pylorilead to DARPP-32 overexpressi...
This oligonucleotide inhibits the function of CREB1 by binding to the CREB1 protein within the cell, thereby preventing it from binding to CRE sites in the regulatory regions of cAMP-responsive genes and activating gene expression. While injection of the CRE oligonucleotide had no effect on STF, ...
Explore all metrics Abstract The analysis of the contributions to synaptic plasticity and memory of cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB has recruited the efforts of many laboratories all over the world. These are six key steps in the molecular biological delineation of short-term memory...
9.Shan G, Bi G, Zhao G, et al.Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer.Respiratory Research.2023, 24(1): 1-15.10.Cui S, Suo N, Yang Y, et al.The aminosteroid U73122 promotes oligodendrocytes generation and myelin formation.Acta ...
Here, we find that cAMP/protein kinase A (PKA)/cAMP responsive element binding protein 1 (CREB1)‐induced miR‐221/222 suppression contributes to the neuron‐like differentiation of gliomas. cAMP agonists selectively induced neuron‐ and astrocyte‐like but not oligodendrocyte‐like differentiation of...
分子机制研究表明,REGγ可与PKAcα相互作用并介导其降解,从而影响CREB1磷酸化,负调控下游产热基因诸如UCP1,PGC1α等的转录表达.综上,本论文发现了REGγ作为棕色和米色脂肪功能的关键负调节因子,并阐明了REGγ通过PKA-CREB信号轴负调控棕色和米色脂肪功能的分子机制.这些结果为深入理解脂质代谢,以及为开发针对REGγ-...
2.Shan G, Bi G, Zhao G, et al.Inhibition of PKA/CREB1 pathway confers sensitivity to ferroptosis in non-small cell lung cancer.Respiratory Research.2023, 24(1): 1-15. 关键词 PKA8BromocAMP sodium salt8-Bromo-cAMP sodium8-Br-Camp sodium8 Bromo cAMP sodium saltRelated Tags: buy 8-...
This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The ...