内cAMP 水平增 加 ,进而激 活其 受体 PKA,活化 下游 CREB,可使下游 BDNF 等细胞因子增加 。因此我们推 测cAMP/PKA—CREB—BDNF 信 号通路 的激 活参与 了, Ro 20—1724 逆转氯胺酮导致的学习记忆障碍。结果显 示,单 纯氯胺 酮麻醉后大 鼠海 马 cAMP 、PKA、CREB、 BDNF 蛋 白都出现了显著下...
(2016) PKA-CREB-BDNF signaling regulated long lasting antidepressant activities of Yueju but not ketamine. Sci Rep 6: 26331.W. Xue, W. Wang, T. Gong et al., "PKA-CREB-BDNF signal- ing regulated long lasting antidepressant activities of Yueju but not ketamine," Scientific Reports, vol. ...
(CBP), and BDNF in the hippocampus were measured to explore the effects and interactions of hypoxia and exercise training on L&M and their relationship with hippocampal PKA-CREB-BDNF signaling pathway, to provide experimental basis for further research on the effects of exercise training on L&M ...
(CBP), and BDNF in the hippocampus were measured to explore the effects and interactions of hypoxia and exercise training on L&M and their relationship with hippocampal PKA-CREB-BDNF signaling pathway, to provide experimental basis for further research on the effects of exercise training on L&M ...
One day post Yueju in Kunming but not ICR strain mice, expression of total and phosphorylated CREB, as well as the CREB signaling activator, PKA (protein kinase A) was up-regulated in the hippocampus. Although BDNF gene expression increased at 3 hours in both strains, it remained up-...
《经rTMS易化的FES对脑梗死使用依赖可塑性cAMP/PKA-MAPK-BDNF-CREB通路的研究》是依托中山大学，由林阳阳担任项目负责人的青年科学基金项目。中文摘要 我们以往研究发现功能性电刺激（FES）通过增强“使用依赖可塑性”改善脑卒中后运动及认知功能，但疗效有限，治疗周期较长，主要考虑与脑梗死...
表达法检测越鞠甘麦大枣汤单次给药30 min和24 h后海马中PKA,CREB,BDNF的蛋白表达.结果 YG在FST中显示出持久的抗抑郁潜力,并且快速逆转了慢性应激小鼠的抑郁样行为.在慢性小鼠模型中,海马中PKA,CREB和BDNF的表达显著上调...
摘要:目的锌是脑正常生理功能的重要微量元素,抑郁症患者血清锌水平降低,经抗抑郁治疗血清锌升高;锌离子稳态的变化会影响cAMP/PKA—CREB—BDNF信号通路中多种信号分子的表达,而cAMP/PKA—CREB—BDNF是抑郁症发病机制中的一种信号通路。锌离子稳态失衡与cAMP)/PKA—CREB—BDNF信号通路的功能改变在抑郁症发病机制中发挥至...
越鞠甘麦大枣汤调节小鼠海马PKA CREB BDNF信号通路的抗抑郁作用