Low-Mg2+ model of epilepsyObjective: To investigate the potential effects of the PKC/CREB pathway on the expressions of GABA(A) receptor subunits alpha 1, gamma 2, and delta in cultured hippocampal neurons using a model of epilepsy that employed conditions of low magnesium (Mg2+)....
PKCε-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis doi:10.1093/cvr/cvv131Protein kinase C epsilonEndotheliumHaem oxygenase-1InflammationApoptosisAims Vascular injury leading to endothelial dysfunction is a characteristic feature of chronic...
Implication of protein kinase C (PKC) in FA-induced IL-11 expression was moreover demonstrated by using RO-31-8220, a PKC inhibitor. We finally showed using SB203580 and RO-31-8220 that phosphorylation of CREB and CREB-promoter activity induced by FA are under the control of both p38 ...
目的:观察和评估"疏肝调神"法针刺对PTSD模型大鼠焦虑,恐惧情绪和终纹床核神经元形态损伤的改善作用,并检测和分析针刺对PKC/ERK/CREB信号通路关键蛋白表达的影响,以揭示和探讨"疏肝调神"法针刺干预PTSD神经损伤的分子生物学机制. 方法:从50只雄性SD大鼠中随机选出10只作为空白组.剩余40只大鼠采用幽闭电击法联合负重力...
人物简介: 一、杨军担任职务:杨军目前担任阳泉经济技术开发区杨军豆腐加工店法定代表人;二、杨军投资情况:目前杨军投资阳泉经济技术开发区杨军豆腐加工店最终收益股份为0%;老板履历 图文概览商业履历 任职全景图 投资、任职的关联公司 商业关系图 一图看清商业版图 ...
(均P<0.05);与UVA暴露组比较,白藜芦醇低,高剂量组OD值,存活率,单细胞克隆形成数目,黑素合成能力,酪氨酸酶水平,PKC,CREB,MITF mRNA蛋白表达水平降低,凋亡率升高,差异均有统计学意义(均P<0.05);与白藜芦醇低剂量组比较,白藜芦醇高剂量组OD值,存活率,单细胞克隆形成数目,黑素合成能力,酪氨酸酶水平,PKC,CREB,...
MAPK- and PKC/CREB-dependent induction of interleukin-11 by the environmental contaminant formaldehyde in human bronchial epithelial cells[J] . Valérie Lecureur,Matthieu Arzel,Sarah Ameziane,Noémie Houlbert,Marc Le Vee,Stéphane Jouneau,Olivier Fardel.Toxicology . 2011 (1)...
The PKCδ and CREB activation could be detected in total cells and in the cell nucleus. Accordingly, a novel CREB binding sequence was detected in the human ptx3 promoter region and could interact with activated CREB in cells challenged with FGF‐2. Surprisingly, the phospholipase D (PLD), ...
目的:研究围生期双酚A(bisphenol A,BPA)暴露对断乳后4周子代雄性小鼠神经行为功能的影响,探讨雌激素受体α(estrogen receptorα,ERα)介导的蛋白激酶C/细胞外调节蛋白激酶/cAMP反应元件结合蛋白(protein kinase C/extracellular signal-regulated kinase/cAMP response element binding protein,PKC/ERK/CREB)信号通路在...
PKCepsilon-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis. Cardiovasc Res. 2015;106(3):509-19. doi:10. 1093/cvr/cvv131.Mylroie, H., Dumont, O., Bauer, A., Thornton, C. C., Mackey, J., Calay, D., et al. (...