Clinical trials during the 1990s and early 2000s focused on the addition of newer agents to gemcitabine. Drugs tested included different classes of cytotoxics and more recently biological agents. Despite some interesting results in phase II settings, the translation of benefit to phase III testing ...
Pitfalls in the Design and Evaluation of Clinical Trials of Intravenously Administered Cardiovascular Drugs 来自 Semantic Scholar 喜欢 0 阅读量: 14 作者: Milton Packer M.D.摘要: Studies that evaluate the efficacy of cardiovascular drugs vary greatly in their protocol design and choice of therapeutic ...
Achieving clinical success will, however, probably require much more investment in basic and experimental research. Here, we address some of the current pitfalls in clinical cell therapy trials and lessons that should be learned as we face the challenges of the future. 展开 关键词:...
There are numerous biases (not all statistical) that can occur in the reporting and interpretation of the results of clinical trials. In this paper we review some of the major sources of such biases and propose some solutions for these problems. In particular, we review the biases that can ...
The systematic review "movement" that has transformed medical journal reports of clinical trials and reviews of clinical trials has taken hold in public he... PD Mullen,G Ramírez - 《Annu Rev Public Health》 被引量: 117发表: 2006年 Reviews of acupuncture for chronic neck pain: pitfalls in ...
Recently, immune checkpoint inhibitor (ICI) has been tested in clinical trials in patients with MMR-deficient (dMMR) CRC and non-CRC pre-treated patients, with promising results. In a phase II trial, anti-programmed cell death protein 1 (PD-1) agents achieved 71% overall response rate in ...
Clinical adjudication is an important step in the trial process, especially given the increased complexity and global scale of clinical trials. Having an independent and unbiased review of clinical events ensures the complete and accurate capture of protocol-driven endpoints. Involving CECs improves the...
Perils and Pitfalls in the Interpretation of Clinical Trials: A Reflection on the Recent Experience in Multiple Sclerosis Therapeutic trials in multiple sclerosis, in part because of the marked intra- and inter-individual variability of its clinical course, are prone to seriou... Douglas S. ;Good...
Common pitfalls in statistical analysis: Intention-to-treat versus per-protocol analysis During the conduct of clinical trials, it is not uncommon to have protocol violations or inability to assess outcomes. This article in our series on common... P Ranganathan,CS Pramesh,R Aggarwal - 《Perspect...
Pitfalls in the design of clinical trials for interstitial cystitis To better understand the association of contaminant uranium with natural organic matter (NOM) and the fate of uranium in ground water, spectroscopic studie... KJ Propert,C Payne,JW Kusek,... - 《Urology》 被引量: 81发表: ...