Clinical trials studying neoadjuvant and adjuvant therapy around prostatectomy for patients with high‐risk prostate cancer have faced multiple challenges. Patients who have a very good response to neoadjuvant therapy may not wish to continue to adjuvant treatment, and prostate‐specific antigen–based ...
Outcome measures utilized in clinical trials of interventions for post-cardiac arrest syndrome: a systematic review. The post-cardiac arrest syndrome (period of critical illness following return of spontaneous circulation [ROSC]) is a promising window of opportunity for c... S Trzeciak,AE Jones,JH...
BACKGROUND: Despite an increased use of patient-reported outcomes (PROs) in oncology clinical trials, integrating the patient perspective into drug approval decisions and documentation has been challenging. OBJECTIVES: To review importan... Alan L Shields,Y Hao,M Krohe,... - 《American Health &...
Clinical trials: Lead candidates that have passed preclinical testing are then tested in human clinical trials to evaluate their safety and efficacy in a larger population. (v) Regulatory approval: If the clinical trials are successful, the drug is then submitted to regulatory agencies for approval...
With three bispecific in the market and the increasing bispecific and trispecifics entering the clinical trials, it is suggested that the coming years will see rrapid approvals of these drugsin the management of several diseases including cancer, auto-immune, HIV, CNS, and others. In addition,...
Innovation in the treatment of disease has been based on clinical trials, and it has worked very well to advance medicine. But something works until it doesn’t work anymore, and we are fast approaching the time when relying on what worked in the past may lead instead to failure if...
Clinically important changes in acute pain outcome measures: a validation study. Measures of pain intensity and pain relief are commonly used outcomes in therapeutic clinical trials. Recent studies of the properties of acute pain measures... JT Farrar,JA Berlin,BL Strom - 《J Pain Symptom Manage...
What is clinically meaningful: outcome measures in pain clinical trials. OBJECTIVE: The goal of this analysis is a better understanding of the issues involved in establishing the amount of change in pain that must be reported by... Farrar,T John - 《Clinical Journal of Pain》 被引量: 253发...
New challenges for nurses in clinical trials - Seminars in Oncology Nursingdoi:10.1016/0749-2081(91)90069-2JenniferL.GuySDOSSeminars in Oncology NursingGuy JL. New challenges for nurses in clinical trials. Semin Oncol Nurs 1991;7(4):297-303....
The uptake of the eCOA/ePRO technologies in clinical trials had been continuously and steadily growing over the recent years. There is no doubt that this trend will remain in place post-pandemic due to the multiple benefits offered by these technologies, particularly their patient-centric cap...