opening specific parts of the genome," said Drouin. "It's what we call a pioneer factor. Acting as a pioneer, Pax7 gives access to 2,500 new sites that transcription factors can bind to and express genes that were previously
To do their job, transcription factors must have access to the right gene at the right time. But only the uncompacted part of the genome is accessible to transcription factors. So, various parts of the genome have to be “opened” to produce different cells. But how?
Almost 20 years after its discovery, multiple combinations of transcription factors have been introduced into cells to screen for cell-type-specific sets of transcription factors, as in the case of iPSC induction. After much effort, defined transcription factors that enable the direct induction of ...
Pioneer factors are transcription factors with the unique ability to initiate opening of closed chromatin. The stability of cell identity relies on robust mechanisms that maintain the epigenome and chromatin accessibility to transcription factors. Pionee
Transcription factor (TF) DNA-binding dynamics govern cell fate and identity. However, our ability to pharmacologically control TF localization is limited. Here we leverage chemically driven binding site restriction leading to robust and DNA-sequence-spe
Lineage-specific transcription factors enable the switch from one cell type into another, with potential applications in disease modeling and regenerative therapy (Takahashi and Yamanaka, 2006). Mouse fibroblasts, for example, have been converted to neurons in vitro by forced expression of the transcrip...
Pioneer transcription factors: establishing competence for gene expression Transcription factors are adaptor molecules that detect regulatory sequences in the DNA and target the assembly of protein complexes that control gene expr... KS Zaret,JS Carroll - 《Genes & Development》 被引量: 1405发表: 20...
2021年3月27日,北京科技大学万向元教授团队在著名国际期刊Plant Biotechnology Journal在线发表了题为“CRISPR/Cas9-based Discovery of Maize Transcription Factors Regulating Male Sterility and Their Functional Conservation in Plants”的研究论文。该研究整合利用生物信息学和花药转录组分析以及CRISPR/Cas9技术,建立起一...
Other genes and transcription factors that affect plant growth and agronomic traits such as yield, flowering, plant growth and/or plant structure, can be introduced or introgressed into plants, see, e.g., WO97/49811 (LHY), WO98/56918 (ESD4), WO97/10339 and U.S. Pat. No. 6,573,430...
Master transcription factors reprogram cell fate in multicellular eukaryotes. Pioneer transcription factors have prominent roles in this process because of their ability to contact their cognate binding motifs in closed chromatin. Reprogramming is pervas