阻断PIEZO1可增强T细胞的牵引力(Credit:Nature Biomedical Engineering) 该研究报道了PIEZO1作为细胞毒性T细胞的机械调节剂的鉴定。当阻断PIEZO1激活时,T细胞介导的肿瘤细胞死亡在体外和体内均增强。PIEZO1负向调节细胞毒性T淋巴细胞(CTLs)...
T cell mechanobiologyFunctional effector T cells in the tumor microenvironment (TME) are critical for successful anti-tumor responses. T cell anti-tumor function is dependent on their ability to differentiate from a nave state, infiltrate into the tumor site, and exert cytotoxic functions. The ...
The mechanical sensor PIEZO1 regulates the traction force that is critical for cytotoxic T cells to target tumour cells. This finding creates avenues for enhancing the efficacy of T cell-targeted immune therapies.
Taken together, our results support Piezo1 as restraining proinflammatory T-cell differentiation while contributing to the generation and persistence of the effector memory pool during CD4+ T-cell–mediated immunopathology. 展开 关键词: CD4+ T cell colitis EAE functional polarization gvHD mechanosensation...
2022年8月22日,北京师范大学生命科学学院刘光伟教授团队、复旦大学杨慧副教授、军事医学研究院毕玉晶研究员团队合作在国际著名期刊eLife发表了题为“Dendritic cell Piezo1 stimulated by mechanical stiffness or inflammatory signals directs the differentiation of Th1 and Treg cells in cancer”的研究论文。该研究发现...
然而,尚不清楚DC的Piezo1信号是否影响肿瘤微环境中不同T细胞亚群的功能分化。 2022年8月22日,生命科学学院刘光伟教授团队、复旦大学杨慧副教授、军事医学研究院毕玉晶研究员团队合作在eLife发表了题为“Dendritic cell Piezo1 directs the differentiation of Th1 and Treg cells in cancer”的研究论文。该研究发现,...
The mechanical properties of WM, such as its elasticity and stiffness, can affect the transmission and propagation of mechanical signals within the brain [7]. At the junction of GM (neuronal cell bodies) and WM (axonal fibers), known as the grey-white matter junction (GW junction), crucial...
PIEZO1 and TRPV4, which Are Distinct Mechano-Sensors in the Osteoblastic MC3T3-E1 Cells, Modify Cell-Proliferation. Int J Mol Sci. 2019;20(19):4960. [44] 王林 , 王熙 , 季楠 , 等 . 机械激活性离子通道压电蛋白 Piezo1 通过 Notch 信号通路介导牙周膜干细胞成骨分化作用机制研究 [J]. 华西 ...
Piezo1, the first mechanosensitive cation channel protein discovered in mammals, acts as a cell membrane mechanoreceptor. It primarily triggers downstream signaling pathways by facilitating Ca2+ influx. In cardiomyocytes, Piezo1 senses tension changes during cardiac contraction and relaxation, regulating ...
2.6 Cell viability assays Cell death and viability were determined by cell counting-8 (CCK-8) assay and live/dead cells assay (Calcein/PI Cell Viability/Cytotoxicity Assay Kit, Beyotime) according to the manufacturer’s instructions. 4T1 cells were seeded into 96-well plates and cultured. After...