标准凝集反应技术用于研究所有与Er相关的反应性抗体和红细胞(red blood cell, RBC)表型,使用的是抗Era(来自P1、P2、P3和P6)、抗Erb(IBGRL参考采集)和抗Er3(来自P10)。对于间接抗球蛋白试验,采用了低离子强度盐水法,其中第二抗体为多特异...
Piezo1 links mechanical forces to red blood cell volume. Elife, 2015, 4. 22. Cheng G, Gao F, Sun X, et al. Paris saponin Ⅶ suppresses osteosarcoma cell migration and invasion by inhibiting MMP-2/9 production via the p38 MAPK signaling pathway. Mol Med Rep, 2016, 14(4): 3199-...
The organization and dynamics of the spectrin–actin membrane cytoskeleton play a crucial role in determining the mechanical properties of red blood cells (RBC). RBC are subjected to various forces that induce deformation during blood microcirculation. Such forces also regulate membrane tension, leading ...
Piezo1 links mechanical forces to red blood cell volume [J]. Elife, 2015, 4: e07370. DOI: 10.7554/eLife.07370. [20] Wang LJ, You XL, Lotinun S, et al. Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk [J]. Nat Commun, 2020, 11 (1):...
The Piezo1 channel opens in response to mechanical stimuli, transducing mechanical signals into an inflammatory cascade in the cell leading to tissue ... Z Ilkan,S Watson,SP Watson,... 被引量: 0发表: 2018年 加载更多来源期刊 eLife,4,(2015-05-08) 研究点推荐 red blood cell volume Red bl...
Karamatic Crew Vet al. Missense mutations in PIEZO1, encoding the Piezo1 mechanosensor protein, define the Er red blood cell antigens.Blood. 2022 Sep 19:blood.2022016504. doi: 10.1182/blood.2022016504. Epub ahead of...
BioArt为您奉上诺奖应景之作——Cell | 机械敏感离子通道蛋白PIEZO1调控铁代谢 铁是人体必需的微量元素,对血红蛋白的生物合成等细胞过程至关重要,但是同时,过多的铁也会对器官造成损伤,引发关节炎,肝功能衰竭和心力衰竭等疾病【1-3】。因此,铁在体内的含量受到严格的控制。
promoting K+ efflux and red blood cell dehydration, causing red blood cell shrinkage; D: Piezo1 is mechanical sensors in cardiomyocytes, directly sensing mechanical forces and converting them into intracellular calcium and ROS signals, maintaining cardiac function homeostasis; E: In fibroblasts, Piezo1...
近日,来自美国霍华德·休斯医学研究所的Ardem Patapoutian教授在Cell发表研究A role of PIEZO1 in iron metabolism in mice and humans,该研究发现机械敏感的离子通道PIEZO1蛋白可调控铁代谢。 遗传性干瘪红细胞增多症(hereditary xerocytosis,HX)是一种...
Piezo1 links mechanical forces to red blood cell volume[J]. Elife, 2015,4DOI: 10.7554/eLife.07370 . 返回引文位置Google Scholar 百度学术 万方数据 [4] 中华医学会围产医学分会胎儿医学学组,中华医学会妇产科学分会产科学组. 非免疫性胎儿水肿临床指南[J]. 中华围产医学杂志, 2017,20(11):769-775...