2021年5月,在Nature communications 杂志上发表了文章“INPP4B promotes PI3Kα-dependent late endosome formation and Wnt/β-catenin signaling in breast cancer”。此报道探讨了INPP4B在ER+乳腺癌中的作用,揭示了一组pik3c突变ER+乳...
In ER+ breast cancer cells, PI3K promotes ligand-dependent and -independent ER transcriptional activity. Models of antiestrogen-resistant breast cancer often remain sensitive to estrogen stimulation and PI3K inhibition, suggesting that clinical trials with combinations of drugs targeting both the PI3K and...
Gedatolisib in combination with palbociclib and endocrine therapy in women with hormone receptor-positive, HER2-negative advanced breast cancer: results from the dose expansion groups of an open-label, phase 1b study. The ...
The new investigational drug alpelisib (Novartis) is an alpha-specific PI3K inhibitor and blocks only the alpha-isoform of the enzyme, which is the one that is mutated in breast cancer. "Previous PI3K inhibitors targeted all four isoforms, so there were a lot of toxicities," explained Fabrice ...
(mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) growth, survival, proliferation, and angiogenesis, which could be an interesting therapeutic target. This review summarizes the PI3K/AKT/mTOR signaling pathway activation mechanism in TNBC and...
May 1;224:109-119. [7]Bhaskar S, et,al. Quercetin attenuates atherosclerotic inflammation and adhesion molecule expression by modulating TLR-NF-kB signaling pathway. Cell Immunol. 2016 Dec;310:131-140.[8]Maugeri A, et,al. Targets Involved in the Anti-Cancer Activity of Quercetin in Breast,...
Jhaveri KL, Im SA, Saura C, et al. Inavolisib or placebo in combination with palbociclib and fulvestrant in patients with PIK3CA-mutated, hormone receptor-positive, HER2-negative locally advanced or metastatic breast cancer: Phase III INAVO120 primary analysis. Cancer Res. 2024;84(7_Suppl):GS...
There is a strong rationale to therapeutically target the phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway in breast cancer since it is highly deregulated in this disease and it also mediates resistance to anti-HER2 therapies. However, initial studi...
乳腺癌(Breast cancer, BC)是危害女性健康的常见癌症,其死亡率也是全球女性癌症患者最高的。术前新辅助化疗(Neoadjuvant chemotherapy, NAC)能减少手术范围,控制肿瘤大小,提高早期乳腺癌的治愈率,已成为广泛应用的术前全身治疗方法。安徽省立医院潘跃银教授团队分别从DNA层面和RNA层面探索了II/III期乳腺癌新辅助化疗响应...
乳腺癌(Breast cancer, BC)是危害女性健康的常见癌症,其死亡率也是全球女性癌症患者最高的。术前新辅助化疗(Neoadjuvant chemotherapy, NAC)能减少手术范围,控制肿瘤大小,提高早期乳腺癌的治愈率,已成为广泛应用的术前全身治疗方法。安徽省立医院潘跃银教授团队分别从DNA层面和RNA层面探索了II/III期乳腺癌新辅助化疗响应...