1.Jank P, Karn T, van Mackelenbergh M, et al. An analysis of PIK3CA hotspot mutations and response to neoadjuvant therapy in breast cancer patients from four prospective clinical trials. Clin Cancer Res. Published online June...
而此次获批基于的INAVO120 III期研究的研究数据也于近日发表在《新英格兰医学杂志》(N Engl J Med),题目为2:Inavolisib-Based Therapy inPIK3CA-Mutated Advanced Breast Cancer。 该研究首次比较了Inavolisib+哌柏西利+氟维司群或安慰剂一线治疗P...
oncogenic pathway alterations and clinical phenotype in patients with metastatic breast cancer (MBC): comprehensive circulating tumor DNA (ctDNA) analysis. Breast cancer research : BCR, 25(1), 112.[
[5].Fusco, N., Malapelle, U., Fassan, M., et al. (2021). PIK3CA Mutations as a Molecular Target for Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer. Frontiers in oncology, 11, 644737. [6].Rosin, J., Svegrup, E., Valachis, A. et al. Discordance of PIK3CA mut...
近日,来自英国伦敦Royal Marsden Hospital and Institute of Cancer Research的Nicholas C. Turner教授携临床团队在The New England Journal of Medicine杂志上发表文章Inavolisib-Based Therapy in PIK3CA-Mutated Advanced Breast Cancer。本临床结果显示,对于PIK3CA突变、激素受体阳性、HER2阴性的局部晚期或转移性乳腺癌患者...
PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 2006; 96: 91-5.Li S, Rong M, Grieu F, Iacopetta B. PIK3CA mutations in breast cancer are associated with poor outcome. Breast Cancer Res Treat 2006; 96(1): 91-95....
[5]Schmidt, C., Stöhr, R., Dimitrova, L., et al. (2024). Quality-Assured Analysis of PIK3CA Mutations in Hormone Receptor-Positive/Human Epidermal Growth Factor Receptor 2-Negative Breast Cancer Tissue. The Journal of Molecular Diagnostics : JMD, 26(7), 624–637.审批编号：CN-147167 ...
[4] NCCN clinical practice guidelines in Oncology: Breast Cancer(2022.V1). [5] Pan, H. et al. 20-year risks of breast-cancer recurrence after stopping endocrine therapy at 5 years. N. Engl. J. Med. 377, 1836–1846 (2017).
最新的2025版《CBCS小红书》也强调了PIK3CA检测的重要性,基于人群的划分,推荐并优化相应的一线、二线治疗策略,包括对PIK3CA突变原发或继发耐药患者,基于INAVO120研究推荐伊那利塞+哌柏西利+氟维司群。 图片来源:2025 CBCS小红书 《中国晚期乳腺癌规范诊疗指南(2024版)》同样强调伊那利塞+哌柏西利+氟维司群可用于治疗...
[1]https://www.targetedonc.com/view/targeting-pik3ca-mutations-in-breast-cancer 关于我们 盛诺一家只做一件事情,就是为国内患者在全球范围内寻找就医途径。只要人类还有办法,不论是创新的药物还是疗法,不论是在美国哈佛,还是英国、日...