[2].Zardavas, D., Te Marvelde, L., Milne, R. L., et al. (2018). Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 36(10), 98...
[1] Scheffler, Matthias et al. “PIK3CA mutations in non-small cell lung cancer (NSCLC): genetic heterogeneity, prognostic impact and incidence of prior malignancies.” Oncotarget vol. 6,2 (2015): 1315-26. [2] Zhang, Lina et al. “PIK3CA gene mutation asso...
[2] Zardavas, D., Te Marvelde, L., Milne, R. L., et al. (2018). Tumor PIK3CA Genotype and Prognosis in Early-Stage Breast Cancer: A Pooled Analysis of Individual Patient Data. Journal of clinical oncology :...
相比PIK3CA野生型患者,PIK3CA突变晚期乳腺癌患者的预后较差,传统治疗效果不佳,临床治疗面临一定的挑战。基于以上背景,医脉通特邀来自安徽医科大学第二附属医院的李烦繁教授,围绕其近期发表于BMC Cancer杂志上的回顾性研究《探究PIK3CA基因突变状...
[9] Guarneri V, Dieci MV, Bisagni G, et al. PIK3CA Mutation in the ShortHER Randomized Adjuvant Trial for Patients with Early HER2(+) Breast Cancer: Association with Prognosis and Integration with PAM50 Subtype. Clin Cancer Res. 2020;...
5. Li S, Shen Y, Wang M, Yang J, Lv M, Li P, Chen Z, Yang J. Loss of PTEN expression in breast cancer: association with clinicopathological characteristics and prognosis. Oncotarget. 2017 May 9;8(19):32043-3...
PIK3CA E545K/E542K are the second most recurrent PIK3CA mutations in breast cancer, and are highly recurrent mutations in many other cancer types. E545K, and possibly the other mutations in the E545 region, may present patients with a poorer prognosis than patients with either patients with ...
[17]Li, S., Shen, Y., Wang, M., et al. (2017). Loss of PTEN expression in breast cancer: association with clinicopathological characteristics and prognosis. Oncotarget, 8(19), 32043–32054. [18]Park J, Cho SY...
These mutations have been observed in up to 40%, 20%, and 21% respectively for each of these cancer types with mutations commonly occurring within the helical exon 9 and kinase domain of exon 20. In breast cancer PIK3CA mutations have been associated with better prognosis, and a greater ...
PIK3CA E545K/E542K are the second most recurrent PIK3CA mutations in breast cancer, and are highly recurrent mutations in many other cancer types. E545K, and possibly the other mutations in the E545 region, may present patients with a poorer prognosis than patients with other PIK3CA variants ...