reduced cost and serum. We made a decision to test the worthiness of VirScan in the follow-up of the cohort of transplant recipients. We enrolled 45 kidney transplant recipients and performed disease serological profiling at day time 0 and day time +365, using VirScan. We compared the full ...
55、ired for full oncogenic activities of BCR/ABL in K562 cells. J Biol Chem 2002; 277: 8076-808249 Okudela K, Hayashi H, Ito T, Yazawa T, Suzuki T, Nakane Y, Sato H, Ishi H, KeQin X, Masuda A, Takahashi T, Kitamura H. K-ras gene mutation enhances motility of immortalized airw...
Full size image Anterior gradient-2 (AGR2) belongs to disulfide isomerase protein family that has a pivotal role in cancer progression. It encompasses a KTEL motif that is a carboxy-terminal endoplasmic reticulum (ER) retention pattern [78,79,80,81,82]. KTEL facilitates the AGR2 attachment ...
A form of programmed cell death that occurs during development and tissue remodellng, in which the cell internally degrades without rupturing the cell membrane, allowing the dead cells to be taken up and degraded by the surrounding cells. Cell senescence A highly stable cell cycle arrest that li...
et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 110, 163–175 (2002). Article CAS PubMed Google Scholar Hara, K. et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110, 177...
Han SS, Yun H, Son DJ, Tompkins VS, Peng L, Chung ST, Kim JS, Park ES, Janz S: NF-κB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma. Mol Cancer 2010, 9 : 97-113. PubMed Abstract BioMed Central Full Text PubMed Central Full Text Return to text...
Full size image Discussion In this study, we used rat endothelial cells and a B16–F10 xenograft model to determine (1) whether exposure to roxarsone induces angiogenesis, (2) whether PI3K/Akt signaling is involved in roxarsone-induced angiogenesis, and (3) whether roxarsone promotes tumor grow...
Vitamin C in an oxidized form (L-dehydroascorbic acid; L-DHA) with antiglycolytic activity can be taken up into CRC cells via the GLUTs. This may provide selective toxicity on CRCSCs and affectCXCR4and stemness markers genes expression in these cells. To this end, we treatedPIK3CA/KRAS-...
Full activation of Akt leads to additional substrate-speci?c phosphorylation events in both the cytoplasm and nucleus, including inhibitory phosphorylation of the pro-apoptotic FOXO proteins(Guertin et al.2006).Fully active PKB/Akt mediates numerous cellular functions including angiogene-sis,metabolism,...
Full size table Expression of upstream components of the PI3K survival pathway (Akt, GSK-3β) were surveyed. The steady-state level of Akt mRNA (Table 1) and phosphorylated protein (Table 2) were increased in the muscles of MSTN-null mice. Differential expression of the GSK-3β was confirm...