Buparlisib (NVP-BKM120; Novartis) is an oral pan-PI3K inhibitor that selectively inhibits all isoforms of class I PI3K (Maira et al.2012). On one hand, buparlisib has shown improved PFS in the clinical development of combined treatment, but on the other hand, it is limited by extensive...
What we learn about a serine and/or threonine protein kinase is that it is a type of enzyme that takes off the -OH ends of the serine and threonine amino acids and replaces the stub where the -OH group used to be with a phosphate group, a PO4(3-). It seems that there is a bi...
We show that CTCFL-driven genes are involved in cytoplasmic membrane functions; in particular, the PI3K-Akt initiators EGFR1 and VEGFA, as well as ITGB3 and ITGB6 are potential drug targets. Finally, we identified the CTCFL targets ACTBL2, MALT1 and PCDH7 as ...
No matter what kind of the genetic alteration happens in PI3K/AKT pathway, or the factor influences cellular behaviors via PI3K/AKT pathway, it leads to the hyper-activation of PI3K/AKT pathway. Growing evidences have shown that the hyper-activation of PI3K/AKT pathway in malignant tumor ...
In addition to these approaches, it is of interest to identify higher-resolution actionable biomarkers that can predict treatment responses and toxicity, and inform personalized treatment decisions. Here, we discuss the current status of PI3K inhibitors in CLL, factors limiting the use of currently ...
performed a comprehensive analysis of PIK3CA-mut in BC to understand to what extent the Therascreen® assay detects most PIK3CA-mut (Martínez-Sáez et al., 2020). They found that N345K mutation in exon four, representing 6% of all tumour samples with PIK3CA-mut, is not included in the ...
What I’m grappling with a little in terms of how to interpret the UNITY-CLL data, particularly in the front-line setting is how to decide on a PI3K over the already excellent outcomes we have with ibrutinib, acalabrutinib, and venetoclax. For me, unless it’s some extreme circumstance ...
It is hypothesized that MFG-E8 may have a favorable influence during the pathological process of TBI. Therefore, the aim of the present study was to investigate the efficacy of MFG-E8 in a TBI mouse model. Materials and methods Animals preparation Adult male Sprague–Dawley (SD) rats weighing...
and angiogenesis. It also plays a pivotal role in cancer progression. Emerging data suggest that the circRNA/PI3K/AKT axis modulates the expression of cancer-associated genes and thus regulates tumor progression. Aberrant regulation of the expression of circRNAs in the circRNA/PI3K/AKT axis is signi...
https://doi.org/10.1038/nature13772 Dewey D (2018) What is comorbidity and why does it matter in neu- rodevelopmental disorders? Curr Dev Disord Rep 5:235–242 Dhillon AS, Hagan S, Rath O, Kolch W (2007) MAP kinase signal- ling pathways in cancer. Oncogene ...