PI-103hydrochloride是有效地PI3K/AktandmTOR抑制剂,对重组PI3K同工型p110α和mTOR的IC50值分别为2nM和30nM。 注:本品仅可用于科研实验,严禁用于临床医疗及其他用途! CAS号:371935-79-4 纯度:99.78% 分子量:384.82 储存条件:-20℃,有效期2年,溶入溶剂后-20℃请尽量在一个月内使用。产品属性: 产品名称 英...
本品是一种常用的phosphatidylinositol 3-kinase (PI3K)抑制剂。LY294002可以通透细胞,特异性抑制PI3K,抑制PI3K/Akt信号途径,包括常见的抑制Akt磷酸化等。LY294002对于纯化的PI3K的IC50为1.4 μM。 CAS:154447-36-6 分子式:C19H17NO3 分子量:307.3 纯度:>98% ...
(Fig. 4g). Upon EGF treatment, an anti-phosphoserine antibody specifically detected pMKRN1, and MKRN1 was stabilized (Fig. 4h). Depletion or inhibition of AKT by short interfering RNA (siRNA) suppressed EGF-driven MKRN1 phosphorylation (Fig. 4i). Finally, phospho-AKT substrate antibody ...
the protein level of each molecule at some earlier time point were checked and the results showed that the expression of phosphorylated AKT was increased at 30 minutes after bleomycin was added, followed by increased expression of ER stress associated proteins including ...
(AKT)/mechanistic target of rapamycin (mTOR) signaling pathway is prevalently over-activated in human cancers and contributes to breast cancer (BC) growth, survival, proliferation, and angiogenesis, which could be an interesting therapeutic target. This review summarizes the PI3K/AKT/mTOR signaling ...
Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse models of anti-hormona... Abstract C169: MM-141, a bispecific antibody inhibitor of PI3K/AKT/mTOR, attenuates tumor growth and potentiates everolimus in mouse ...
结果与对照组相比，在表达野生型KIT及其突变体的B aF3细胞中，P I3K8亚型特异性抑制剂对KIT及其下游信号分子蛋白激酶B(AKT)和胞外信号调节激酶（ERK)活化的抑制作用最强，其次为 P I3K a和P I3KP亚型特异性抑制剂。在G IST-T1细胞中，P I3KP亚型特异性抑制剂对KJT及其下游信号活化的抑制作用最强,其次为P...
Given that the PI3K/AKT pathway has manifested its compelling influence on multiple cellular process, we further review the roles of hyperactivation of PI3
Western blot analyses were performed three to six times, depending on the antibody with similar outputs. Full size image PTEN inhibits the CAV1/β-catenin immunocomplex According to ingenuity pathway analysis, PTEN and β-catenin share 63 interactors (Fig. 2a), including CAV1, AKT, platelet ...
Using a human phospho-kinase antibody array, Akt1/2 signaling, known to regulate Nanog, was found to be highly activated in sarcoma spheroid cells compared with monolayer cells. Pharmacologic inhibition of Akt using LY294002 and Akt1/2 knockdown using shRNA in sarcoma CSCs decreased Nanog ...