PI3K/AKT / mTORRPE cellsInsulin positively correlates with the length of the eye axis and is increased in the vitreous and serum of patients with pathological myopia (PM). How insulin influences the physiological process of retinal pigment epithelial (RPE) cells in PM remains unclear. This study...
In NSCLC, the PI3K/Akt/mTOR pathway has been heavily implicated in both tumorigenesis and the progression of disease. A number of specific inhibitors of PI3K, Akt and mTOR are currently under development and in various stages of preclinical investigation and in early phase clinical trials for ...
PI3K/AKT/mTOR pathwayvitamin DVitamin D deficiency is associated with acute myocardial infarction (AMI); thus we aimed to explore improvement effects of 1,25ヾihydroxyvitamin D3 (VD3) on the AMI and its potential mechanism. AMI models were constructed using male C57/BL6J mice and randomly ...
Methylation of NRN1 is a Novel Synthetic Lethal Marker for Combined PI3K‐Akt‐mTOR and ATR InhibitorsATR inhibitorDNA Damage RepairDNA methylationNRN1PI3K signalingdoi:10.1111/cas.14917John Wiley & Sons, LtdCancer Science
Purpose: To find a new strategy to treat cisplatin‐resistant head and neck squamous cell carcinoma (HNSCC), we investigated the effects of EGFR inhibitors on the PI3K/Akt/mTOR pathway and determined the efficacy of EGFR inhibitors in combination with PI3K inhibitors to suppress cell pro...
WB was used to detect the expression levels of PI3K‐AKT‐mTOR pathway related proteins. Results: Our findings showed that LAIR‐1 can inhibit cell viability, colony formation and invasion in vitro. Meanwhile, LAIR‐1 significantly downregulated the expression of PI3K, p‐AKT and p‐mTOR...
In addition, neutralization of Toll‐like receptor 4 could restore the expression of Foxp3, PI3K, and its downstream effectors induced by ESA. Collectively, the findings indicated that ESA inhibited Foxp3 expression via the upregulation of PI3K‐AKT‐mTOR signaling pathway....
Furthermore, Spi significantly upregulated miR‐34a and miR‐125b that have a key role in the progression of PI3K/AKT/mTOR pathway. This is the first in vivo report on the chemo‐preventive effect of Spi against glioblastoma, suggesting its potential use in the chemoprevention of this cancer ...
Tumor‐associated macrophages secrete CCL2 and induce tamoxifen resistance by activating PI3K/Akt/mTOR in breast cancerdoi:10.1111/cas.14230Dongbo LiHongfei JiXingjian NiuQingyuan Zhang
4E-BP1 regulates the sensitivity of human glioma cells to chemotherapy through PI3K/Akt/mTOR-independent pathway. Neuropathology. 2014 Jun;34(3):227-35.Zhu HL, Xie SM, Fang M, Zhang JJ, Weng ZP, Zhong XY: 4E-BP1 regulates the sensitivity of human glioma cells to chemotherapy through PI3K...