ActivationGraft-versus-host diseaseT cells, which has not been reported previously. The present model can be utilized to study human immune cell function in vivo and elucidate the mechanisms underlying the pathogenesis of human GVHD. In addition, this model system can help researchers to rapidly ...
Chimeric antigen receptor T (CAR-T) cell therapy holds great promise as an innovative immunotherapeutic approach for cancer treatment. To optimize the production and application of CAR-T cells, we evaluated the in vivo stability and efficacy capacities of CAR-T cells developed under different conditi...
Phytohemagglutinin (PHA) has mitogenic and potent cell agglutinating activities. It binds to T-cell membranes and stimulates cell division and metabolic activity. PHA has the ability to stimulate close contacts between cell membranes.PHYTOHEMAGGLUTININ PHA-M Preparation Products And Raw materials Raw mat...
The response of human peripheral blood lymphocytes to phytohemagglutinin: Determination of cell numbers Optimization and definition of conditions for studying lymphocyte function in vitro resulted in exponential proliferation of lymphocytes from day 2 to day 5 with an average doubling time of 20 hr. The...
This reagent is intended for use in in vitro activation of human and mouse leukocytes.Reported ApplicationFunctional Assays For Research Use Only. Not for use in diagnostic procedures. Specifications Quantity100 μL FormLiquid Product LineeBioscience™ Product TypePhytohemagglutinin-L (PHA-L) Solution...
In: Lucas DO (ed) Regulatory Mechanism in Lymphocyte Activation. Academic Press, New York, p 464 3. Booss1, Wheelock EF 1977 Progressive inhibition ofT-cell function preceding clinical signs of cytomegalovirus infection in mice. J Infect Dis 135:478 4. Carr MC, Stites DP, Fudenberg HH 1972...
Lymphocyte ActivationRosette FormationDose-Response Relationship, DrugCell DivisionAdultInosineThe Authors investigated the effect of methisoprinol (Inosiplex) on separated B and T lymphocytes from 8 healthy donors. B or T treated cells, recombined with T or B untreated cells, were subsequently mi ...
The splenic plaque-forming-cell (PFC) response of mice to immunization with pneumococcal capsular polysaccharide (SSS-III), coupled with T-cell activation by phytohemagglutinin (PHA), is characterized by enhanced numbers of IgG-producing cells, largely restricted to the IgG2a and IgG2b subclasses. ...
(1990) Accessory cell-derived helper signals in human T-cell activation with phytohemagglutinin: induction of interleukin-2, responsiveness of interleukin-6, and production of interleukin-2 by interleukin-l. Cytokine, 2, 45.Kuhweide R, Van Damme J, Lorre K, Baroja ML, Tsudo M, Ceuppens JL:...
BACKGROUND Progesterone is an endogenous immunomodulator that suppresses T cell activation during pregnancy. The stimulation of membrane progesterone receptors (mPRs) would seem to be the cause of rapid non-genomic responses in human peripheral T cells, such as an elevation of intracellular calcium (...