We tested other forms of T cell activation and found phytohemagglutinin (PHA) distinctive in the ability to markedly expand CD8 T cells in this model. IFN纬 or iNOS inhibition was not necessary for this response. PHA triggered less IFN纬 production and inhibitory PD-L1 expression than TCR ...
CD3 pathway of T-cell activation. II. Role of HLA-class I molecules in early events. The role of distinct regions of HLA class I molecules in regulating T-cell activation via the CD3-antigen receptor complex was investigated. Monoclonal ant... R Schwab,ME Weksler,C Russo - 《Cellular Immu...
人骨髓MSC对PHA活化T细胞周期以及表型和细胞因子分泌的影响
Activation of PHACTR2 with oral NIM-1001 treatment enhances regulatory CD4+ T cell function and provides protection from systemic lupus erythematosus doi:10.4049/jimmunol.210.Supp.238.06Phosphatase and actin regulator 2 (PHACTR2) is an RPEL domain containing protein recently shown to be ...
T cell receptor (TCR) ligation and protein kinase C (PKC) activation stimulate proliferation and modulate apoptosis in both mammalian and amphibian lymphocytes. The potential relationship between apoptosis and the cell cycle in mature Xenopus laevis splenic lymphocytes is addressed by monitoring apoptosis...
Stimulation of these cells with phorbol esters, such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and either lectins, such as phytohaemagglutinin (PHA) or monoclonal antibodies leads to activation of T cell antigen receptors and induction of IL-2 expression. Because these cells can produce IL-2...
Inhibition of T cell responses by activated human CD8+ T cells is mediated by interferon-gamma and is defective in chronic progressive multiple sclerosis. The autologous mixed lymphocyte reaction (AMLR) involves the activation of T cells by autologous antigen presenting cells. Cells are generated ...
hepcidin gene. Activin B may also induce hepcidin synthesis through SMAD 1/5/9 pathway, independently of IL-6 pathway. Intracellular liver iron seems to induce BMP6 synthesis. (C) IL-6 modulates hepcidin synthesis through activation of signal transducer and activator of transcription 3 (STAT3)....
Colchicine-sensitive structures and lymphocyte activation. In purified human peripheral blood lymphocytes, low (0.01–10 μM) concentrations of cytochalasins A B, E and D (CA, CB, CD, CE) produced marked augmentation of transport and metabolic responses to phytohemagglutinin (PHA) and concanaval....
Phytohemagglutinin (PHA) has mitogenic and potent cell agglutinating activities. It binds to T-cell membranes and stimulates cell division and metabolic activity. PHA has the ability to stimulate close contacts between cell membranes.PHYTOHEMAGGLUTININ PHA-M Preparation Products And Raw materials Raw mat...