When a plasma-concentration curve is constructed for different patients that have been given an identical dose of an identical drug, interindividual differences are noted. Besides some very obvious causes, such as body weight and body composition, some other factors involved in the interindividual ...
Influence of the perimenopause on cardiovascular risk factors and symptoms of middle-aged healthy women. Arch Intern Med. 1994;1542349- 2355ArticlePubMedGoogle ScholarCrossref 83. Perry 3rd HM The endocrinology of aging. Clin Chem. 1999;451369- 1376PubMedGoogle Scholar 84. Greendale GAJudd HL...
This conference was held at The Royal Olympic Hotel in the centre of Athens (Greece) during the 1-2 of October in 2007. The issues discussed in the conference involved physiological factors affecting drug absorption, the role of pre-systemic effects on bioavailability (BA), the impact of ...
Physiological considerations bearing on the controlle entry into the systemic circulation of orally administered drugs in healthy man are reviewed. The most desirable site for drug absorption is the sterile portion of the small intestine, so that the time window available for absorption is not greater...
However, the delivery of effective drug dosage to the corneal epithelium by eye drops is challenging due to fast tear dilution and physiological barriers. One possibility is intraocular drug delivery, which however is more invasive and requires surgery or injection. As an alternative, the sustained ...
Quantitative analysis of efficacy and associated factors of calcium intake on bone mineral density in postmenopausal women. Osteoporos Int. 2017;28(6):2003–10. Article CAS PubMed Google Scholar Thulkar J, Singh S, Sharma S, Thulkar T. Preventable risk factors for osteoporosis in postmenopausal...
A method of enhancing transdermal delivery of a pharmaceutically active drug from a transdermal delivery system as well as a transdermal delivery system capable of providing a desirable flow interface
Factors affecting biliary excretion include drug characteristics (chemical structure, polarity and molecular size), transport across sinusoidal plasma membrane and canniculae membranes, biotransformation and possible reabsorption from intrahepatic bile ductules. Intestinal reabsorption to complete the enterohepatic ...
The precise power demands of the sensor device 500 will depend on numerous factors, including the frequency of measurements, the frequency and required range of data transmission to an external device, etc. However, additional, or fewer, fuel cells can be used depending upon the power ...
Dual regulation of calcium oscillation in astrocytes by growth factors and pro-inflammatory cytokines via the mitogen-activated protein kinase cascade In response to neurotransmitters, astrocytes show various types of calcium increase (transient, oscillatory, and complex), the physiological significance o.....