Factors that affect the absorption of cyclosporin A (CsA) were examined in gentamicin-induced acute renal failure (ARF) rats. In ARF rats, the area under the blood CsA concentration-time curve after oral administration was significantly decreased in comparison with that of control rats; 5.81 卤 ...
多股软铜引线与扁铜引线焊接时，应先将多股软引线端头用细铜线绑扎并打扁，在导线上搭接的长度应为导线宽度的（）倍
Absorption of drugs from the gastrointestinal tract is a complex process the variability of which is influenced by many physicochemical and physiologic factors. The two most important physicochemical factors that affect both the extent and the rate of absorption are lipophilicity and solubility. The ...
Genetic studies provide a novel approach to identify individuals susceptible to CTR-CVT. Genetic variations can impact cardiac susceptibility to drugs through various mechanisms. Some genetic alterations affect the transport of antitumour drugs in the body [8,9], and others influence drug metabolism [...
There is also the fear that plant sterols, particularly esters, could affect the absorption of fat soluble vitamins. However, no direct evidence points at plant sterols being in some way dangerous for children. Studies with small amounts of plant sterols fed to infants have shown that neonates ...
It was generally recognized some years ago that a solid drug product had to disintegrate into small particles and release the drug before absorption could take place. For the purpose of monitoring uniform tablet disintegration, the Unite State Pharmacopoeia (USP) established an official disintegration ...
Genetic factorsplay an as yet poorly defined role in therapeutic drug monitoring, as is the case of the poor ability of some racial groups to acetylate drugs Concomitant disease, ie whether there are underlying conditions that may affect drug distribution or metabolism, eg renal disease with ↓ ...
Unfortunately, all these therapeutics are associated with increased risk of MRONJ. It is also well established that BP have antiangiogenic properties6,7,8,9 and therefore are effective at inhibiting tumor angiogenesis.10 Antiangiogenesis drugs affect wound healing and the resulting effects on bone ...
they are in the hundreds of 1000s of Daltons [in size],” Sukuru pointed out. “However, there are a lot of efforts going on, and novel formation and answers are showing good promise, where they open the tight junctions, facilitating the absorption of the molecules,” he added. Another...
What is the cause of diarrhea most often in children and infants?Causes can include: Rotavirus, also known as viral gastroenteritis or stomach flu, which is the most common cause of diarrhea in children ages 2 and younger. However, viral gastroenteritis can also affect adults. ...