Diminished wave reflection in the aorta: a novel physiological action of insulin. Hypertension 1999;33:1118 -22.Westerbacka J, Wilkinson I, Cockcroft J, et al. Diminished wave reflection in the aorta a novel physiological action of insulin on large blood vessels. Hypertension 1999, 33: 1118–...
and insulin/IGF-I hybrid receptors in addition to IR; 3) high concentrations of insulin (>or=1-5 nM) activate IGF-IR and hybrid receptors as well as IR; and 4) this crossover activation can confound interpretation of studies of insulin action in ECs when high insulin concentrations are ...
Ribonucleic acid synthesis during the early action of thyroid hormones 1. The effect on RNA synthesis in rat liver of thyroidectomy and the administration of thyroid hormone, especially during its physiological latent period, ... JR Tata,CC Widnell - 《Biochemical Journal》 被引量: 566发表: 1966...
The problem is part of the wider one of the relation between chemical structure and physiological action. In those cases where the chemical structure is known, it is easy to investigate the action of known quantities of the drug upon a number of organisms of the same or different species and...
In order to obtain a new understanding of the complexities of T3 action in vivo and the role of TRs during development, many mouse models of disrupted or augmented thyroid hormone signalling have been generated. The aim of this review is to provide a picture of the physiological actions of ...
L. Regulation of the hypothalamic–pituitary–adrenal axis by cytokines: actions and mechanisms of action. Physiol. Rev. 79, 1–71 (1999). Article CAS PubMed Google Scholar Cannon, W. Organization for physiological homeostasis. Physiol. Rev. 9, 399–431 (1929). This classic theoretical ...
Intracellular monosaccharide and amino acid concentrations and activities and the mechanism of insulin action Current amino acid and monosaccharide transport models are based on an assumption which equates the intracellular chemical activity of a solute with its co... SB Horowitz,TW Pearson - 《Molecula...
Diabetes mellitus (DM) is a chronic metabolic disease characterized by elevated blood glucose levels resulting from impaired insulin secretion/action and glucose homeostasis [1]. The global prevalence of DM has markedly increased during the last few decades, from 4.7% in 1980 to about 10.5% in 20...
It plays a key role in glucose homeostasis by counteracting the action of the hypoglycemic hormone insulin and strongly contributing to the correction of hypoglycemia. Its main effect is to stimulate glucose output from the liver. The mechanisms by which glucose controls glucagon secretion are still ...
Using VDR knockout mice, it has been shown that rapid (non genomic) action of 1α,25(OH)2-D3 on osteoblast ion channel requires the presence of a functional vitamin D nuclear/caveolae receptor [55], [56]. Binding of 1α,25(OH)2-D3 to the caveolae-associated VDR results in the ...