Drug effects that increased insulin secretion resulted in the best model fit, thus identifying the primary mechanism of action of Gb and metabolites as insulin secretagogues. The model also quantified the combined effect of Gb, M1 and M2 to have a fourfold maximal increase on endogenous insulin ...
Defects in both insulin secretion and insulin action exist in patients with non-insulin-dependent diabetes mellitus (NIDDM). The loss of the acute plasma insulin response to intravenous glucose is seen in patients with relatively mild degrees of fasting hyperglycemia, but patients with severe fasting...
Glucocorticoid-induced insulin resistance. The importance of postbinding events in the regulation of insulin binding action and degradation in freshly isol... importance of post- binding events in the regulation of insulin binding, action, and degradation in freshly isolated and primary cultures of rat...
a被研磨2h超细铝粉在超声波作用下发生水解反应 Is ground the 2h superfine aluminite powder to have the hydrolitic reaction under the supersonic wave action [translate] awhere we took photos 那里我们采取了相片 [translate] aintended to be an exhaustive list of all such trademarks. [translate] a...
Two types of evidence support the conclusion that patients with NIDDM are resistant to the biological actions of insulin. First, patients with NIDDM have a diminished response to exogenously administered insulin. Sophisticated methods have been developed to measure insulin action in vivo, e.g., ...
insulin reaction, insulin shock - hypoglycemia produced by excessive insulin in the system causing coma 5. shock - an instance of agitation of the earth's crust; "the first shock of the earthquake came shortly after noon while workers were at lunch" seismic disturbance earthquake, quake, seism...
[translate] aThe effect of metformin on insulin signaling transduction represent a primary mechanism of metformin action in insulin resistant state. metformin的作用在胰岛素信号转导在胰岛素抗性状态代表metformin行动一个主要机制。 [translate] 英语翻译 日语翻译 韩语翻译 德语翻译 法语翻译 俄语翻译 阿拉伯语翻译...
The effect of metformin on insulin signaling transduction represent a primary mechanism of metformin action in insulin resistant state. 酷G2细胞慢性胰岛素曝光通过PI3K路导致胰岛素信号转导的downregulation。 metformin的作用在胰岛素信号转导在胰岛素抗性状态代表metformin行动一个主要机制。 [translate] ...
This study shows that GABAB1 receptors localize to primary cilia of β-cells in pancreatic islets of Langerhans to induce selective Ca2+ influx in the cilium via voltage-dependent Ca2+ channel activation, and that GABA action depends on restricted Ca2+ diffusion between the cilium and cytosol. ...
Figure 1. Mechanisms of action of ICIs in cancer treatment.19,20 ICIs are monoclonal antibodies that enhance the immune system by blocking checkpoint proteins, such as CTLA-4 and PD-1, that are located on the surface of immune cells (such as CD8+ T cells) and, in the case of PD-L1,...