In upper body obesity, portal ... MD Jensen - 《Journal of Clinical Endocrinology & Metabolism》 被引量: 730发表: 2008年 Acute effects of insulin in the control of VLDL production in humans. Implications for the insulin-resistant state. The role of hyperinsulinemia in the pathogenesis of ...
OBJECTIVE—The aim of this study was to investigate the impact of 9 days of bed rest on insulin secretion, insulin action, and whole-body glucose and fat metabolism in first-degree relative (FDR) and matched control (CON) subjects. RESEARCH DESIGN AND METHODS—A total of 13 FDR and 20 CO...
This study tests the hypothesis that sex differences in regional fat distribution contribute to a disparity in insulin sensitivity in older men vs. older women. Healthy, older (50–71 years), sedentary men (n = 28) and women (n = 29) were recruited to participate in the study. Body fat...
Insulin resistance, a harbinger of the metabolic syndrome, is a state of compromised hormonal response resulting from the dysregulation of a wide range of insulin-controlled cellular processes. However, how insulin affects cellular energy metabolism via long-term transcriptional regulation and whether boos...
The hypothalamus plays an important role in energy homeostasis: the regulation of the body'senergy balance. Special neurons in this part of the brain, known as POMC cells, react to neurotransmitters and thus control eating behaviour andenergy expenditure. The hormone insulin is an important messenger...
BACKGROUND AND OBJECTIVES: Insulin has several physiologic actions that include stimulation of cellular glucose and potassium uptake. The ability of insulin to induce glucose uptake by cells is impaired in type 2 diabetes mellitus, but whether potassium uptake is similarly impaired is not known. This...
The Insulin Receptor: Its Role in Insulin Resistance of Obesity and Diabetes In recent years, techniques have become available to study the interaction between insulin and its cellular receptors. This has led to an explosion of info... Olefsky,M J. - 《Diabetes》 被引量: 484发表: 1976年 ...
Controversy exists as to whether there are differences in insulin action between older men and women, and what factors contribute to these differences. This study tests the hypothesis that sex differences in regional fat distribution contribute to a disparity in insulin sensitivity in older men vs. ...
and in those with central or peripheral obesity.study of basal and insulin-stimulated 2-deoxyglucose uptake in human omental and subcutaneous adipose tissue explants derived from patients undergoing elective abdominal surgery.Fourteen lean (average age 47 y, average body mass index (BMI) 22 kg/m)...
The interaction of insulin and insulin receptor was studied with epididymal fat cell membrane of Zucker fatty rats and compared with their thin littermates or wild type normal rats. Epididymal fat pads were removed from Zucker fatty rats (10-11 months old, body weight 600-700 g) and from th...