For populations in Western societies, the predominant problem in glucose metabolism is diabetes mellitus although other derangements are significant but not often encountered. Of all the humoral and neuronal regulatory mechanisms for glucose metabolism, insulin is the hormone that lowers serum glucose ...
OBJECTIVE—The aim of this study was to investigate the impact of 9 days of bed rest on insulin secretion, insulin action, and whole-body glucose and fat metabolism in first-degree relative (FDR) and matched control (CON) subjects. RESEARCH DESIGN AND METHODS—A total of 13 FDR and 20 CO...
This sort of damage blunts insulin sensitivity and, if prolonged, also glucose-stimulated insulin release. Such chronic lipotoxicity is provided by postprandial hyperlipidemia and marked postabsorptive lipolysis from (abdominal) fat stores in ... WK Waldh?Usl,M Roden - 《Current Opinion in Endocrinol...
Insulin resistance, a harbinger of the metabolic syndrome, is a state of compromised hormonal response resulting from the dysregulation of a wide range of insulin-controlled cellular processes. However, how insulin affects cellular energy metabolism via long-term transcriptional regulation and whether boos...
Controversy exists as to whether there are differences in insulin action between older men and women, and what factors contribute to these differences. This study tests the hypothesis that sex differences in regional fat distribution contribute to a disparity in insulin sensitivity in older men vs. ...
Adipose tissue is now recognized to have a multitude of functions that are of importance in the regulation of energy balance and substrate metabolism. Diff... F Giorgino,L Laviola,J.W. Eriksson - 《Acta Physiologica Scandinavica》 被引量: 485发表: 2005年 Insulin-like growth factor binding pr...
p values indicate significance of differences among pairs of the groups analyzed by ANOVA. BMI, body mass index; FPG, fasting plasma glucose; PG, plasma glucose; PG60 (120), PG at 60 (120) min; FPI, fasting plasma insulin; PI, plasma insulin; PI60 (120), PI at 60 (120) min; BP...
No studies are available that have compared early defects in glucose metabolism in the offspring of insulin-deficient and insulin-resistant probands with non-insulin-dependent diabetes mellitus (NIDDM). To investigate this issue, we evaluated insulin secretion capacity with oral and intravenous glucose ...
摘要: Presents a study that investigated the effect of insulin and abundant amino acid supply on protein metabolism in skin wounds. Concentrations of essential amino acids in skin wounds; Determination of plasma amino acid concentrations; Examination of protein kinetics in skin wounds....
Insulin resistance differentially affects the PI 3-kinase– and MAP kinase–mediated signaling in human muscle We sought to identify the pathways compromised in insulin resistance and to test the effect of moderate exercise on whole-body and cellular insulin action... ...