TAF15 appears to be one of multiple PKA substrates that undergo RNA-binding dynamics upon phosphorylation. We observed that the activation of the cAMP-PKA signaling axis caused a change in the composition of a collection of RNA species that interact with TAF15. This obser...
The presence of a peptide inhibitor of PKA had no consequence on viral replication in a melanoma cell line whereas in fibroblasts, it resulted in a drastic decrease of replication. An overall analysis of PKA substrates phosphorylation patterns during VZV replication showed that the phosphorylation of...
1e). We then examined the role of PKA in glucose-induced H3K4me3 in deletion mutants of TPK1, TPK2, and TPK3, which encode the catalytic subunits of PKA. These three Tpks have distinct substrates and different functions in cellular processes36. For example, Tpk1, but not Tpk2 and Tpk...
Protein phosphorylation is a reversible PTM that is mediated by kinases and phosphatases, which phosphorylate and dephosphorylate substrates, respectively. These two families of enzymes facilitate the dynamic nature of phosphorylated proteins in a cell. Indeed, ...
phosphorylated substrates of PKA (P-PKAs), protein tyrosine phosphorylation (PTP), global protein acetylation (Pan-Kac) and 伪-tubulin acetylation (Tub-Kac) was greater in sperm of fresh semen samples with relatively greater motility than in sperm of fresh semen samples with relatively lesser ...
Protein phosphorylation is a reversible PTM that is mediated by kinases and phosphatases, which phosphorylate and dephosphorylate substrates, respectively. These two families of enzymes facilitate the dynamic nature of phosphorylated proteins in a cell. Indeed, the ...
Sperm motility variables were determined using computer-assisted sperm analysis (CASA) and the phosphorylation of PKA substrates, tyrosine residues and AMP-activated protein kinase (AMPK) were analyzed by Western blot. Moreover, intracellular sperm-specific glyceraldehyde 3-phosphatedehydrogenase (GAPDH) ...
PP2A-B55: substrates and regulators in the control of cellular functions Priya Amin Sushil Awal Anna Castro Oncogene(2022) SILAC kinase screen identifies potential MASTL substrates Kamila A. Marzec Samuel Rogers Andrew Burgess Scientific Reports(2022) ...
CFTR was phosphorylated in vitro by PKA, PKC, or PKG on the same sites that were phosphorylated in CF-2. Kinetic analysis of phosphorylation of CF-2 and of synthetic peptides confirmed that these sites were excellent substrates for PKA, PKC, or PKG. CFTR was immunoprecipitated from T84 ...
- 《Journal of Pharmacology & Experimental Therapeutics》 被引量: 84发表: 1994年 Cardiac troponin T, a sarcomeric AKAP, tethers protein kinase A at the myofilaments. Efficient and specific phosphorylation of PKA substrates, elicited in response to 尾-adrenergic stimulation, require spatially confined...