This is mediated through protein kinase A (PKA)-dependent phosphorylation of, among others, phospholamban (phosphorylation removes its inhibiting role on SERCA2 Ca2+ pumping) and cardiac troponin I (phosphorylation decreases myofilament calcium sensitivity). Calcium release and reuptake as well as ...
PKAPublic Key Authentication(computing) PKAPrivate Key Access PKAPublic Key Authentication PKAPrimary Key Attribute PKAPohjois-Karjala(Finland) PKAPublic Key Algorithm PKAProfessionally Known As PKAPrimary Knock-on Atom PKAPhilip Koether Architects(est. 1994) ...
intraperitoneal adipose tissue weight, serum LDL-c, FFA, total cholesterol (TC), triglyceride (TG), leptin , IL-6 concentration and liver TG and TC levels, and increased serum adiponectin levels, promoted the phosphorylation of AMPKα, and inhibited the transcriptional regulator...
Because IAA is a weak acid (pKa = 4.75), a portion of it is lipophilic in its protonated form at apoplastic pH (≈5.5); nevertheless, cellular uptake across the plasma membrane was shown to be dependent on AUX1/LAX proteins functioning as high-affinity auxin-proton symporters [21,22...
Its protonated form, the hydroperoxide radical, is a dangerous oxidant, but only at low pH values [5] (pKa = 4.88). As membrane surfaces are negatively charged, proton concentrations are higher and therefore, hydroperoxide radicals become more abundant [6]. As hydroperoxide radicals are un...
The effect is significantly reduced for neurons dialyzed with H-89 (PKA inhibitor) but not chelerythrine (PKC inhibitor) suggesting that phosphorylation state modulates GABAA receptor sensitivity to the inhibitory effect of waglerin-1 [96]. Interestingly, on the basis of waglerin, a tripeptide ...
The general consensus is that cold stimulates a greater release of catecholamines by the nervous system, an event that stimulates thermogenesis through the activation of protein kinase A (PKA) and p38 mitogen-activated protein kinases (p-38 MAPK) pathways followed by the activation of uncoupling pro...
whichthenassociateswiththecatalyticsubunitofmyosinlightchainkinase-phosphorylatesserine19ontheregulatorylightchainofmyosin.PhosphorylationofSer19allowsthemyosinATPasetobeactivatedbyactinandthemuscletocontract.•Calciumregulationisvital•Insmoothmuscle,thecytosolicfreeCa2+concentrationis~0.1mMinbasalstate;~10,000times...
PDK in turn blocks pyruvate conversion to acetyl-CoA in the mitochondria, thereby decreasing oxidative phosphorylation (OXPHOS)-mediated ROS production. Under normoxic conditions (sky blue color; right side of the diagram), UCP1 can generate heat in the process of electron transport chain-mediated ...
More recently Jarome and colleagues [116] found that CaMKII (but not PKA) increased phosphorylation of the Rpt6 subunit protein and increased proteasome activity in rat brain tissue. These data suggest that the melatonin/calmodulin interaction and non-receptor-mediated actions of melatonin may be ...