TDP‐43Here, we report a case of Cockayne syndrome (CS) in a Japanese man who displayed a unique pathology of phosphorylated trans-activation response (TAR) DNA-binding protein 43 (pTDP-43) with abundant Rosenthal fibers. Many round pTDP-43-positive structures were detected throughout the ...
HLA-DR, CD74, CD68, and Iba1), a neuronal marker, an astrocyte marker, and pathological phosphorylated TDP-43 (pTDP-43). Single-cell levels of microglial functional markers were
Thus, dash-like pTDP-43 aggregates are regularly seen in motor neurons in ALS and may represent the initial cellular lesion in this disease. Because these aggregates were not stained with antibodies against p62 and non-phosphorylated TDP-43, it is possible that phosphorylation of TDP-43 is ...
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation Recently, 43-kDa TAR DNA-binding protein (TDP-43) was identified as a component of ubiquitinated inclusions (UIs) in sporadic amyotrophic lateral sclerosis... CF Tan,H Eguchi...
Development of tau-based therapies for Alzheimer’s disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across four
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P1-140: Aggregation of phosphorylated and ubiquitinated TDP-43 in SH-SY5Y cells 2008, Alzheimer's & Dementia more Takashi Nonaka, Tetsuaki Arai, Haruhiko Akiyama, Emanuele Buratti, Francisco E. Baralle, Masato Hasegawa P1-140: Aggregation of phosphorylated and ubiquitinated TDP-43 in SH-SY5Y cel...
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclero- sis. Ann Neurol 2008;64:60-70.M Hasegawa,T Arai,T Nonaka.Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Annals of Neurology . 2008...
Background: Phosphorylated and proteolytically cleaved TDP-43 is a major component of the ubiquitin positive inclusions in the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Intracellular accumulation of TDP-43 has been observed in...
The distribution of these TDP-43 positive structures was largely consistent with that of argyrophilic grains. Double-labeling confocal microscopy revealed, however, that many of phospho-TDP-43 positive structures were not colocalized with phospho-tau staining. Colocalization of phospho-TDP-43 and ...