Background: Phosphorylated and proteolytically cleaved TDP-43 is a major component of the ubiquitin positive inclusions in the most common pathological subtype of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). Intracellular accumulation of TDP-43 has been observed in...
Thus, dash-like pTDP-43 aggregates are regularly seen in motor neurons in ALS and may represent the initial cellular lesion in this disease. Because these aggregates were not stained with antibodies against p62 and non-phosphorylated TDP-43, it is possible that phosphorylation of TDP-43 is ...
Development of tau-based therapies for Alzheimer’s disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across four
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P1-140: Aggregation of phosphorylated and ubiquitinated TDP-43 in SH-SY5Y cells 2008, Alzheimer's & Dementia more Takashi Nonaka, Tetsuaki Arai, Haruhiko Akiyama, Emanuele Buratti, Francisco E. Baralle, Masato Hasegawa P1-140: Aggregation of phosphorylated and ubiquitinated TDP-43 in SH-SY5Y cel...
TDP‐43Here, we report a case of Cockayne syndrome (CS) in a Japanese man who displayed a unique pathology of phosphorylated trans-activation response (TAR) DNA-binding protein 43 (pTDP-43) with abundant Rosenthal fibers. Many round pTDP-43-positive structures were detected throughout the ...
Akiyama, Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis, Ann. Neurol. 64 (2008) 60-70.Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Hashizume Y, Beach TG, Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama H (...
TDP-43Primary age-related tauopathyAlzheimer’s diseaseNeurofibrillary tangleHippocampusPrimary age-related tauopathy (PART) is characterized by tau neurofibrillary tangles (NFTs) in the absence of amyloid plaque pathology. In the present study, we analyzed the distribution patterns of phosphorylated 43-...
Aggregation of hyperphosphorylated TDP-43 is the hallmark pathological feature of the most common molecular form of frontotemporal lobar degeneration (FTLD–TDP) and in the vast majority of cases with amyotrophic lateral sclerosis (ALS–TDP). However, most of the specific phosphorylation sites remain ...
Plasma phosphorylated TDP-43 levels are elevated in patients with fron- totemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation. J Neurol Neurosurg Psychiatry (2014) 85:684-91. doi:10.1136/jnnp-2013-305972Suarez-Calvet M, Dols-Icardo O, Llado A, Sanchez-Valle R, ...