The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro Article Open access 15 March 2021 SNAP-25, but not SNAP-23, is essential for photo
Macroautophagy has previously been implicated in the clearance of various proteins implicated in human neuro- degenerative syndromes including Alzheimer precursor protein (APP), α-synuclein, TDP-43, tau, and huntingtin [22-29]. However, direct in vivo evidence of an essential role for macro...