N.V.BHAGAVAN, inMedical Biochemistry (Fourth Edition), 2002 Control of Glycogen Phosphorylase Regulation of glycogen phosphorylase in muscle is accomplished by many of the same enzymes that control glycogen synthesis. Phosphorylase kinase converts the dimeric phosphorylase from the inactive to the active...
Purine base⇌Pi, Phosphorylaseribose-l-Pribonucleoside →kinaseATP ribonucleotide Although purine nucleoside Phosphorylase is known to function in the catabolism of purine nucleosides (see Chapter 10), there is in fact no evidence that it functions as indicated in this scheme. Thus, in cel...
S Nakielny,DG Campbell,P Cohen - 《European Journal of Biochemistry》 被引量: 214发表: 1991年 Phosphorylation and inactivation of glycogen synthase by phosphorylase kinase Soderling TR, Svrivastava AK, Bass MA, Khatra BS (1979 a) Phosphorylation and inactivation of glycogen synthase by phosphorylase...
Possibly activation of TFT by thymidine kinase (TK) is very efficient, preventing inactivation by TP. Trifluorothymidine possibly acts by TS inhibition and DNA incorporation. However, orally administered TFT in combination with TPI (TAS-102) seems to prevent systemic degradation (e.g. liver) of ...
Fig. 1. Pathways of deoxyguanosine (dGuo) metabolism in human T-cells. The normal function of deoxycytidine (dCyd) kinase is salvage of dCyd arising from apoptosis of other T-cells. It is regulated by dCMP product inhibition. Excess dGuo is phosphorylated to dGMP by the same enzyme, but...
rmGPa and hlGPa were prepared by phosphorylation of rmGPb and hlGPb, respectively, performed using a truncated form of the γ (catalytic) subunit of rabbit skeletal muscle phosphorylase kinase produced as described previously [26]. Kinetic studies were performed at 30 °C in the direction of ...
Their glycosyl phosphate reaction products can enter various pathways, such as glycolysis, without prior activation by a kinase, saving one molecule of ATP [4]. Because of the reversibility of the phosphorolytic reaction, GPs are also attractive enzymes for the synthesis of glycosidic bonds in ...