Very prominent were ten SNPs, which were all located in a putative phosphoinositide phosphatase SAC9 on chromosome 2 and showed very high effects on rooting percentage after 6 weeks of more than 40% difference between nulliplex and quadruplex genotypes. SAC9 was reported...
2005. Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumu- lation of PtdIns(4,5)P2 and constitutive expression of the stress-response pathway. Plant Physiology 138: 686-700.Williams, M.E., Torabinejad, J., Cohick, E., Parker, K., Drake, E.J., ...
The biology and role of PTEN in human cancers has been reviewed in detail elsewhere (9, 10). Promiscuous PIP Phosphatases: the Sac1-Like Proteins The Sac1-like class of enzymes encode “multi” phosphatase activities that cleave the D-3, D-4, and D-5 position phosphates from PI(3)P,...
Article: The phosphoinositide phosphatase Sac1p controls trafficking of the yeast Chs3p chitin synthase
Synaptojanin 2 (SYNJ2) harbors two distinct phosphatase domains: SAC1-like and 5-phosphatase domains which hydrolyze PI(4,5)P2 and PIP3 in vitro [159]. SYNJ2 controls clathrin-mediated endocytosis and cell growth [118], [160], [161]. SYNJ2 is a regulator of hair cell survival and its...
Sac phosphatase domain proteins. Biochem J 2000; 350(Part 2):337–352. Article CAS PubMed PubMed Central Google Scholar Haffner C, Takei K, Chen H, et al. Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15. ...
Saccharomyces cerevisiae cells deficient in enzymes involved in PIP metabolism-Sac1p, a phosphoinositide phosphatase(5), and Vps34p and Pik1p, a PI 3-... MR Wenk,L Lucast,GD Paolo,... - 《Nature Biotechnology》 被引量: 376发表: 2003年 TOR2 Is Part of Two Related Signaling Pathways Coo...
Preliminary data using a malachite green assay to detect free phosphate and thin-layer chromatography suggest that the Sac9 protein has 5-phosphatase activity specific to catalyzing the hydrolysis of the 5-phosphate of PtdIns(4,5)P2.Utah State University.Drake, Elizabeth J....
2011. Unique cell wall abnormalities in the putative phosphoinositide phosphatase mutant AtSAC9. Planta, in press.Vollmer AH, Youssef NN, DeWald DB. 2011. Unique cell wall abnormalities in the putative phosphoinositide phosphatase mutant AtSAC9. Planta. 234:993-1005....
SYNJ1 and SYNJ2 show the presence of a SAC at the N terminus, an RRM domain next to the PI 5-phosphatase domain; and a PR domain at the C terminus (93). INPP5E or pharbin is composed of a PR domain at the N terminus and a CAAX sequence at the C terminus (94). PIPP and ...