Phosphoinositide-specific phospholipase C (PLC) comprises a family of multidomain phosphodiesterases. The family mediates signaling responses including the classically described conversion of PtdIns(4,5)P2 to Ins(1,4,5)P3, a Ca2+-mobilizing second messenger, and diacylglycderol, a protein kinase C...
Expression of phosphoinositide-specific phospholipase C isoenzymes in cultured astrocytes. J Cell Biochem 100(4): 952–959.Lo Vasco VR, Fabrizi C, Fumagalli L, Cocco L (2010) Expression of phosphoinositide specific phospholipase C isoenzymes in cul- tured astrocytes activated after stimulation ...
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As the production of PtdIns-3,4,5-P3is critical for a number of physiological responses in cells, mechanisms exist which mediate the termination of PI 3-K and PtdIns-3,4,5-P3signaling. PI 3-K lipid products, including PtdIns-3,4,5-P3, are not degraded by phospholipases, but instead...
This chapter describes a recently developed assay for carbachol-activated, guanine nucleotide-dependent phospholipase C stimulation using crude membrane preparations from rat brain cortex. The procedure is generally applicable to most brain regions, and it has been successfully used with rabbit brain. The...
Multiple roles of phosphoinositide-specific phospholipase C isozymes BMB Rep., 41 (2008), pp. 415-434 Google Scholar 3 Astle M.V., K.A. Horan, L.M. Ooms, C.A. Mitchell. The inositol polyphosphate 5-phosphatases: traffic controllers waistline watchers and tumour suppressors? Biochem. Soc....
As highlighted in this review, the phosphoinositide-phospholipase C pathway is strongly implicated in the control of mouse oocyte meiosis. The pathway becomes progressively functional as oocyte growth advances, and it appears to play a role in the G2/M transition when meiosis resumes, at least in...
Phosphoinositide specific phospholipase C and mitogenic signalling. DY Noh - 《Biochem.biophys.acta》 被引量: 398发表: 1995年 Epidermal growth factor receptor-mediated cell motility: phospholipase C activity is required, but mitogen-activated protein kinase activity is not suffici... Gupta, and A...
The fission yeast plc1 + gene encodes phosphoinositide-specific phospholipase C. The two- hybrid interaction assay with plexA-plc1 + as a bait revealed that Plc1p interacted with the 14-3-3 proteins Rad24p and Rad25p. Formation of a complex containing Plc1p and Rad24p in vivo was confirme...
L. (1999) Mammalian phosphoinositide-spe- cific phospholipase C. Biochim. Biophys. Acta. 1441, 255-267.Williams, R. L. 1999. Mammalian phosphoinositide-specific phospholipase C. Biochim Biophys Acta 1441:255-267.Williams, R. L. (1999) Mammalian phosphoinositide-specific phospholipase C. ...