phosphatasephosphoinositidetumoursuppressorThe activity of biological molecules is often affected by their phosphorylation state. Regulatory phosphorylation operates as a binary switch and is usually controlled by counteracting kinases and phosphatases. However, phosphatidylinositol (PtdIns) has three phosphorylation...
phosphoinositide 5-phosphatase 中文名: 中文别名: CBNumber: CB37250993 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商2 phosphoinositide 5-phosphatase化学性质 安全信息 phosphoinositide 5-phosphatase性质、用途与生产工艺 phosphoinositide 5-phosphatase上下游产品信息 ...
aggregation, aggresome, neurodegenerative disease, neuron, Parkinson disease, phosphatidylinositol phosphatase, phospholipid, proteasome, ArPIKfyve-Sac3 complex, Synphilin-1The 5-, whose loss-of-function mutations are linked to , forms a stable cytosolic complex with the ArPIKfyve. The ArPIKfyve-...
J. et al. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 3, 117–130 (2003). Article CAS PubMed Google Scholar Blind, R. D., Suzawa, M. & Ingraham, H. A. Direct modification and activation of a ...
aPTEN (phosphatase and tensin homolog deleted on chromosome ten), a recently discovered tumor suppressor gene, appears to negatively control the phosphoinositide 3-kinase signaling pathway for regulation of cell proliferation and cell survival by dephosphorylating the phosphatidylinositol 3,4,5-triphosphate...
To investigate the effect of Jianpijiedu Fang (JPJDF) on phosphatase and tensin homolog (PTEN), phosphoinositide 3-kinase (PI3K), and focal adhesion kinase (FAK), and on the survival of hepatocellular carcinoma (HCC) nude mice. Forty male nude mice were randomly divided into 4 groups. Human...
Although the phosphatidylinositide phosphatase Inpp5B was recruited to nascent phagosomes, it rapidly detached from the membrane after phagosomes sealed. Detachment of Inpp5B required the formation of PI(3)P. Thus, class III PI3K activity was also required for the accumulation of PI(4,5)P2 ...
protein phosphatase 1c gammainterferenceArticles and research papers on cell division, cell structure, animal and plant cell biology and cell cycles.doi:10.1038/ncb949Plattner, RinaIrvin, Brenda J.Guo, ShulingBlackburn, KevinKazlauskas, Andrius
Williams ME, Torabinejad J, Cohick E, Parker K, Drake EJ, Thompson JE, Hortter M, Dewald DB (2005) Mutations in the Arabidopsis phosphoinositide phosphatase gene SAC9 lead to overaccumulation of PtdIns(4,5)P2 and constitutive expression of the stress- response pathway. Plant Physiol 138: ...
This is the case for two members of the PI 5-phosphatase SKIP and SHIP2. Both enzymes are in ruffles, plasma membranes, the endoplasmic reticulum, a situation that is unique for SKIP, and the nucleus. Following localization, PI 5-phosphatases act on specific cellular pools of PIs, which ...