Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin. Structure. 2005; 13 :277–286.Edlich C,Stier G,Simon B,Sattler M,Muhle-Goll C. Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human ...
39,40. More recently, the related phosphatidylinositol 3,4-bisphosphate (PI(3,4)P2) has also been demonstrated to be more than just a byproduct of PIP3degradation and
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Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate. Science 275, 665–668 (1997). Article CAS PubMed Google Scholar Klippel, A., Kavanaugh, W. M., Pot, D. & Williams, L. T. A specific product of phosphatidylinositol 3-kinase directly activates ...
Novel function of phosphatidylinositol 4,5-bisphosphate as a cofactor for brain membrane phospholipase D J. Biol. Chem., 269 (1994), pp. 21403-21406 View in ScopusGoogle Scholar Nakanishi et al., 1993 H. Nakanishi, K.A. Brewer, J.H. Exton Activation of the ζ isozyme of protein kinase...
Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate The regulation of the serine-threonine kinase Akt by lipid products of phosphoinositide 3-kinase (PI 3-kinase) was investigated. Akt activity was found to ... Franke,F T. - 《Science》 被引量: 3567发...
while most of the C-terminal residue peaks remained detectable (Fig.6b). The driving forces of the binding seem to involve electrostatic contacts between the negative charges of the three phosphate groups in PIP3and the positively charged N-terminal domain in αSyn. However, the hydrophobic NAC...
This review focuses on the mechanisms by which the production of a common product, PIP3, can produce isoform-specific signaling by PI 3-kinases.Editor's suggested further reading in BioEssays: Phosphatidylinositol 4,5-bisphosphate: Targeted production and signaling AbstractHow does SHIP1/2 balance ...
phosphatidylinositol 4-kinase PKB protein kinase B PMSF phenylmethylsulfonyl fluoride SF Steel factor or stem cell factor SHIP SH2-containing inositol-5-phosphatase PI(4)P phosphatidylinositol 4-phosphate PI(3 4)P2, phosphatidylinositol 3,4-bisphosphate PI(4 5)P2, phosphatidylinositol 4,5-bisphosphate...
Local synthesis of the phosphatidylinositol-3,4-bisphosphate lipid drives focal adhesion turnover 2022, Developmental Cell Citation Excerpt : Rho family GTPase-activating proteins (GAPs) frequently harbor lipid-binding domains (Amin et al., 2016), suggesting that PI3K-C2β activity may directly regulat...