A large part of the magnesium in cells is bound to ATP, and the magnesium-ATP complex is a factor in muscle relaxation. A deficiency of either ATP or magnesium contributes to muscle cramping. When a cell is stimulated, causing ATP to release inorganic phosphate, it also releases magnesium. ...
Glucose also feeds amino acid synthesis, including of serine, glycine, aspartate, glutamate, proline, and glutamine (but not asparagine). Downstream in glycolysis, tumor pyruvate and lactate labeling exceed that found in serum, indicating that lactate exchange via monocarboxylic transporters is less ...
Two cDNAs (AtPT1 and AtPT2) encoding plant phosphate transporters have been isolated from a library prepared with mRNA extracted from phosphate-starved Arabidopsis thaliana roots. The encoded polypeptides are 78% identical to each other and show high degree of amino acid sequence similarity with high...
The amino acid sequences deduced from the three nucleotides were 32-42% homologous with microbial phosphate transporters of Saccharomyces cerevisiae (PHO84), Neurospora crassa (PHO-5) and Glomus versiforme (GvPT). PHT1, PHT2, PHT3 and PHT6 were clustered in a 25-kbp region of chromosome V...
transporters, but it does share some features of dicarboxylate carriers70 and contains a cluster of conserved and asymmetric amino acid residues at the middle of the membrane (Figure 10(d)), consisting of R225, Q226, and R317, which are contact points II and III of the common substrate ...
Amino acid transporters in cancer and their relevance to “glutamine addiction”: novel targets for the design of a new class of anticancer drugs. Cancer Res. 75, 1782–1788 (2015). Article CAS PubMed Google Scholar Lo, M., Wang, Y. Z. & Gout, P. W. The xc− cystine/glutamate ...
In humans, these transporters participate in key physiological processes and are also, as in the case of members of the organic anion transporter (OAT) family, of pharmaceutical interest. Recently, crystal structures of two bacterial representatives of the MFS family u2014 the glycerol-3-phosphate ...
Pht1-type Pi-transporters from plants Similarity between amino acid sequences of Pht1 family of plant phosphate transporters Pht2;1 encodes a low-affinity Pi-transporter Pht2;1 is primarily expressed in shoots Effects of P supply on expression of hvpt genes in barley roots and shoots Phosphate...
Sphingosine 1-phosphate (S1P) is a biologically active lipid that promotes tumour growth, neovascularization and inflammation. It regulates the growth, survival and migration of mammalian cells through both intracellular and receptor-mediated mechanisms. S1P is formed by the sphingosine kinase (SK)-catal...
This mainly includes carbohydrate and polyol transporters as well as ammonia and amino acid permeases, indicating a restriction in nutrient availability encountered by intracellular Cr. neoformans cells (Derengowski Lda et al., 2013; Fan et al., 2005). In summary, the utilization of carbohydrates...