Furthermore, we explore the possibility of targeting amino acid transporters to improve immune disorders and cancer immune therapies.doi:10.1016/j.jphs.2021.09.006Keitaro.HayashiDepartment of Pharmacology and Toxicology, Dokkyo Medical University School of Medicine, Shimotsuga, Japan. Electronic address: ...
Amino acid transport in mammals is mediated by many kinds of amino acid transporters. 哺乳动物氨基酸的跨膜运输由多种氨基酸转运载体蛋白介导,其中L型氨基酸转运载体1(LAT1)属于L系统,主要转运大分子支链氨基酸和芳香族中性氨基酸。 2. This article mainly discussed members of neutral,acidic and basic amino...
The L-type amino acid transporter (LAT) family are Na(+)-independent transporters, which deliver neutral amino acids into cells. The four LATs, LAT1 (SLC7A5), LAT2 (SLC7A8), LAT3 (SLC43A1) and LAT4 (SLC43A2), are responsible for the majority of cellular leucine uptake. They show...
Morimoto, E.Establishment and characterization of mammalian cell lines stably expressing human L-type amino acid transporters.J. Pharmacol. Sci.108, 505–516.https://doi.org/10.1254/jphs.08232FP(2008). ArticleCASPubMedGoogle Scholar Shibahara, Y.et al.Aromatase inhibitor treatment of breast cancer...
LAT1 deletion in keratinocytes does not dampen the inflammatory response or their proliferation, which could be maintained by increased expression of the alternative amino acid transporters LAT2 and LAT3. Specific deletion of LAT1 in γδ and CD4 T cells controls the inflammatory response induced ...
Insights into L-type heteromeric amino acid transporters Simon Newstead Nature Structural & Molecular BiologyNews & Views03 Jun 2019 Nature Structural & Molecular Biology (Nat Struct Mol Biol)ISSN1545-9985(online)ISSN1545-9993(print) Sign up for theNature Briefing: Cancernewsletter — what matters ...
Amino acid transporters play an important role in supplying nutrients to normal and cancer cells for cell proliferation. System L is a major transport syst... DK Kim,SK Song,IJ Kim,... - 《Journal of the Korean Society of Food Science & Nutrition》 被引量: 0发表: 2004年 Human L-type...
L-type amino acid transporter 1 (LAT1) is one of the L-type amino acid transporters, and transports large neutral amino acids such as leucine, isoleucine, valine, phenylalanine, tyrosine, tryptophan, methionine and histidine [9, 10]. LAT1 requires covalent association with the heavy chain of...
To identify the major transport mechanisms of L-theanine, we screened for candidate transporters of L-3H-theanine in several mammal cell lines that intrinsically express multiple transporters with various specificities. All of the cells tested, T24, HepG2, COS1, 293A, Neuro2a, and HuH7, ...
Placental amino acid transporters and peroxisome proliferator-activated receptors (PPARs) have been implicated to placental development and therefore regulation of fetal growth. We analyzed the correlation between the expression of amino acid transporter