but can occur later; phenytoin should be discontinued at the first sign of a rash unless the rash is clearly not drug-related; if signs or symptoms suggest SJS/TEN, discontinue therapy permanently and consider alternative therapy; evaluate ...
Impact of phenytoin therapy on the skin and skin disease. Expert Opin Drug Saf 2004;3(6):655–65.Impact of phenytoin therapy on the skin and skin disease. Expert Opin Drug Saf - ScheinfeldScheinfeld N. Impact of phenytoin therapy on the skin and skin disease. Expert Opin Drug Saf 2004;...
However, in the event of an allergic or hypersensitivity reaction, more rapid substitution of alternative therapy may be necessary. In this case, alternative therapy should be an anticonvulsant drug not belonging to the hydantoin chemical class. Suicidal Behavior And Ideation Antiepileptic drugs (AEDs)...
Arthritis as a rare side effect of phenytoin therapy 来自 国家科技图书文献中心 喜欢 0 阅读量: 19 作者:P Carfagna,E Pistella,V Paravati,P Serra 摘要: Anticonvulsant hypersensitivity syndrome is an uncommon side effect of phenytoin. It is characterized by fever, skin reactions, lymphadenopathy, ...
Effect of Anticonvulsant Drugs on Plasma Total Cholesterol, High-Density Lipoprotein Cholesterol, and Apolipoproteins A and B in Children with Epilepsy The effect of long-term anticonvulsant drug therapy with phenobarbital, phenytoin, carbamazepine, primidone, and valproic acid in epileptic children on ...
Black, in Side Effects of Drugs Annual, 2016 Phenytoin Phenytoin, an anti-convulsant, is used in conjunction with cranial radiation therapy for treatment of brain tumors; erythema multiforme has been reported to develop in patients receiving such a treatment combination. A report described a 41-...
Anticonvulsant effect: 10–20 mcg/mL.Antiarrhythmic effect: 10–20 mcg/mL.Extended-release phenytoin sodium, peak: 4–12 hours.Therapeutic plasma concentrations, oral: Achieved after about 1 week of therapy.Following oral administration, therapeutic plasma concentrations can be obtained more rapidly ...
DESIGN: We selected and screened for mutations a group of 24 epileptic patients who experienced significant gingival overgrowth following phenytoin therapy. Mutation scanning was carried out by denaturing high-performance liquid chromatography analysis of the entire coding region of the SOS1 gene. Novel ...
Immunosuppression is a recognised side effect of anticonvulsant therapy. We presen... CM Rice,SL Johnston,DJ Unsworth,... - 《Journal of Neurology Neurosurgery & Psychiatry》 被引量: 16发表: 2007年 Plasma exchange in the successful treatment of drug-induced renal disease. Both patients had ...
In our study, sex, age age at onset of therapy, treatment duration, and oral hygiene were not significantly associated with the risk of developing gingival overgrowth. A direct relationship with daily dose was found to be an independent risk factor. Younger age and poorer oral hygiene seemed ...