Nystagmus, seizures, and ataxia are the most common of these; rarely, serious events such as psychosis, delirium, and coma have been reported.1,2 Although some references list specific phenytoin levels for certain adverse events, these cannot be relied on completely...
The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for DILANTIN and any potential adverse effects on the breastfed infant from DILANTIN or from the underlying maternal condition. Pediatric Use Initially, 5 mg/kg/day in two or three ...
Rapid intravenous administration increases the risk of adverse cardiovascular reactions, including severe hypotension and cardiac arrhythmias; in pediatric patients, administer the drug at a rate not exceeding 1 to 3 mg/kg/minute or 50 mg per minute, whichever is slower; although the risk of cardiov...
Consider known benefits of breast-feeding along with the woman's clinical need for phenytoin and any potential adverse effects on the breast-fed infant from the drug or underlying maternal condition.Geriatric UseClearance may be reduced in geriatric patients.Geriatric patients may show early signs of...
Phenytoinis a common AED that has been in use since the 1950s. A large volume of literature suggests that it has a number of adverse effects, including sedation[81], psychosis[83], and encephalopathy[82]. It has been studied in bipolar disorder and found to be superior to placebo when ...
4.Objective to study the effects of hemoperfusion on the patients with severe phenytoin sodium intoxication. 目的研究血液灌流对严重苯妥英钠中毒患者的治疗作用。 5.Objective To investigate the rules and characteristics of adverse drug reactions ( ADR ) of phenytoin sodium. ...
Chronic administration of phenytoin has been associated to have a number of adverse effects. Falling serum folate levels is one such most often reported adverse drug sequelae of long term phenytoin usage. Folates administered at pharmacological doses, on the other hand, have been blamed for a dec...
CYP2C9 polymorphisms and phenytoin metabolism: implications for adverse effects INTRODUCTION: Phenytoin, a widely prescribed old-generation antiepileptic drug, requires careful individualization of dosage to compensate for its prominen... V Franco,E Perucca - 《Expert Opin Drug Metab Toxicol》 被引量...
IV administration should not exceed 50 mg/min in adults or 1 to 3 mg/kg/min or 50 mg/min (whichever is slower) as there is a risk of adverse cardiovascular reactions with rapid IV administration For non-emergency therapy, consider slower IV administration or intermittent infusion ...
Treatment of Adverse Effects Treatment of poisoning with phenytoin tends to be sup- portive. Repeated doses of activated charcoal may be given orally to adults and children who have ingested more than 20 mg/kg; the aim is not only to prevent ab- sorption but also to aid elimination. ...