Phenytoin is a widely prescribed antiepileptic drug with a narrow therapeutic index and significant interindividual variation. It requires therapeutic drug monitoring due to its metabolism to inactive compounds by specific enzymes, leading to the need for personalized dosing in patients. ...
Therapeutic drug monitoring is necessary for optimal dosing During IV therapy, continuous monitoring of the electrocardiogram and blood pressure; observe for signs of respiratory depression Monitor for emergence or worsening of depression, suicidal thoughts or behavior, and/or any unusual changes in mood...
Learning Objectives: Achieving therapeutic levels of phenytoin is critical to its efficacy and safety. Free serum levels represent pharmacologically active phenytoin, about 10%, due to the high protein binding of the drug. Predicting free serum levels, or total levels corrected for low albumin, i...
Pharmacogenetics: the therapeutic drug monitoring of the future? Genetic variability in drug response occurs as a result of molecular alterations at the level of drug-metabolising enzymes, drug targets/receptors, and dru... MHH Ensom,TKH Chang,P Patel - 《Clinical Pharmacokinetics》 被引量: 182...
High blood sugar(hyperglycemia), resulting from the drug's inhibitory effect oninsulinrelease reported; phenytoin may also raise serum glucose level in patients withdiabetes mellitus; use caution. Not indicated for seizures resulting fromhypoglycemiaor other metabolic causes; appropriate diagnostic procedures...
A low level of high-density lipoprotein cholesterol (HDL-C) is an important and common risk factor for coronary heart disease. Cross-sectional studies and uncontrolled clinical trials have suggested that phenytoin can significantly raise HDL-C levels. This study was undertaken to determine whether ph...
Hyperglycemia, resulting from the drug's inhibitory effects on insulin release, has been reported. Phenytoin may also raise the serum glucose level in diabetic patients. Serum Phenytoin Levels Above Therapeutic Range Serum levels of phenytoin sustained above the therapeutic range may produce confusional...
In order to explore the therapeutic potential of Nav1.5 expression in BCa, we next tested the effect of a widely used VGSC-blocking anticonvulsant drug, phenytoin (50 μM), on Na+current in BCa cells, using whole-cell patch clamp recording. This concentration is within the serum therapeutic ...
capecitabinedruginteractionphenytoinrectalcancerPhenytoin toxicity occurs when serum levels exceed the therapeutic level, leading to symptoms such as nystagmus, ... Clare,McGrath,Amy,... - 《Cureus》 被引量: 0发表: 2018年 加载更多来源期刊 Reactions Weekly 研究点推荐 capecitabine phenytoin complex part...
Ther Drug Monit 1979; 1: 277–83. 2. Bollini P, et al. Decreased phenytoin level during antineoplastic therapy: a case report. Epilepsia 1983; 24: 75–8. 3. Sylvester RK, et al. Impaired phenytoin bioavailability second- ary to cisplatinum, vinblastine, and bleomycin. Ther Drug Monit ...