least once a month to ensure consistency. Additionally, if dosages are increased or decreased, testing should be done within a week of the adjustment. If a patient has an increase in seizure activity or the side effects experienced, the levels should be checked and dosages adjusted accordingly...
Salivary phenytoin levels are approximately 10% of the total serum level in treated epileptic patients and in normal subjects after ingestion of a single oral dose. The half time of disappearance of phenytoin after 100 or 300 mg doses is 12.2±3.0 (SD) h in serum and 12.3±3.2 (SD) h ...
These results show the importance of the genetic polymorphism analysis of the main metabolizing enzyme groups of phenytoin for the dose adjustment.AydanDepartmentOzkaynakciDepartmentMedineDepartmentIdrizogluDepartmentGulcebiDepartmentDenizDepartmentErgeç...
Decreased level of consciousness: The mechanism for this effect has not been established. With Intravenous Use ▪ Hypotension Important Notes ▪ As is the case with a number of other antiepileptic drugs, phenytoin is teratogenic. This is particularly problematic because phenytoin also induces the ...
If you become pregnant while taking DILANTIN, the level of DILANTIN in your blood may decrease, causing your seizures to become worse. Your healthcare provider may change your dose of DILANTIN. If you take DILANTIN during pregnancy, your baby is also at risk for bleeding problems right after ...
277-83. 2. bollini p, et at. decreased phenytoin level during antineoplastic therapy: a ca::.e report. i983; 24: 75-8. 3. sylvester rk, et impaired phenytoin bioavailability secondary to cisplatinum, vinblastine, and bleomycin. ther drng monit 1984; 6: 302-5. 4. grossman sa, et ...
Decreased phenytoin level during antineoplastic therapy: a case report. Epilepsia 1983; 24: 75–8. 3. Sylvester RK, et al. Impaired phenytoin bioavailability second- ary to cisplatinum, vinblastine, and bleomycin. Ther Drug Monit 1984; 6: 302–5. 4. Grossman SA, et al. Decreased phenytoin ...
Statistical tests were two-sided at a 5% significance level; results are presented with 95% CIs. The primary outcome was analysed using the log-rank test and is presented as a Kaplan-Meier curve. All participants were followed up to cessation of convulsive status epilepticus, with censoring used...
The metabolism of Phenytoin to the major metabolite, 5-(p-hydroxyphenyl)-5-(phenylhydantoin, is saturable, giving rise to a non linear dose-serum concentration relationship. Therefore, the dose range compatible with a therapeutic serum concentration is narrow within subjects, and monitoring serum con...
Have or had diabetes. Your blood sugar level can be altered while taking DILANTIN If you take DILANTIN during pregnancy, your baby is at risk for serious birth defects and bleeding problems right after birth. Your healthcare provider may give you and your baby medicine to prevent this. All ...