Gustafsson LL, Rombo L, Alvan G, Bjorkman A, Lind M, et al. On the question of dose-dependent chloroquine elimination of a single oral dose. Clinical Pharmacology and Therapeutics 34: 383–385, 1983 ArticlePubMedCASGoogle Scholar Haapasaari J, Wuolijoki E, Ylijoki H. Treatment of juvenil...
Pharmacokinetics is the study of how a patient's body will process a substance from introduction to elimination. Basically, it's the journey the substance encounters as it makes its way through the body and what the body does to it. Please don't confuse it with Pharmacodynamics, which is th...
reversal of respiration lag behind intramuscular naloxone in overdose victims. The intraindividual, interindividual and between-study variability in pharmacokinetics in volunteers are large. Variability in the target population is unknown. The duration of action of 1 mg intravenous (IV) is 2 h, possibl...
The exact number of compartments depends on the question the researcher wishes to answer and the governing physiological processes that are important to the chemical of interest. Usually, organs with similar pharmacokinetics and not considered to be the target organs can be grouped together for ...
There is a great deal of discrepancy between various reports on CYP alterations during HF, likely due to differences in disease severity, the species in question and other underlying conditions. A recent review by Aspromonte et al.217 has summarized a comprehensive modulation of cardiac CYP in ...
We will request consent from participants for their inclusion in the study, which will include the collection of blood samples for the purpose of assessing the safety of the drug in question and the incidence of infection in mosquitoes.
upper case peaNephrectomyUnilateralAmikacinmonth肾切除术丁胺卡那霉素As unilateral nephrectomy is not a rare surgical procedure, it gives rise to the question whether drugs predominantly eliminated through the urinary tract can be handled effectively by the remaining kidney. Amikacin is predominantly ...
Results of the subjective effects assessment indicate that NPs may appeal to some smokers, scoring higher than both the gum and lozenge for the question ‘How much did you like the product?’, with 55% of subjects giving positive scores. Although the gum scored poorly for this question, it ...
within individuals. The decay after this dose was estimated using the same model as that describing the pharmacokinetics after iv administration, using individual estimates for the subject in question. 2.3.3Oral Population Pharmacokinetic Model First-order absorption, with and without a lag time or ...
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