Where would you like to go now? Top 200 Drugs Ask Math Questions Ask A Pharmacy Tech Question Site Map
upper case peaNephrectomyUnilateralAmikacinmonth肾切除术丁胺卡那霉素As unilateral nephrectomy is not a rare surgical procedure, it gives rise to the question whether drugs predominantly eliminated through the urinary tract can be handled effectively by the remaining kidney. Amikacin is predominantly ...
, (c) Since most reports on the beneficial effects of polyphenols are based on in vitro cell culture studies, the question still remains, whether similar doses will yield identical effects in whole body? Polyphenols are also reported to cross-react with other biological antioxidants and microbial...
The exact number of compartments depends on the question the researcher wishes to answer and the governing physiological processes that are important to the chemical of interest. Usually, organs with similar pharmacokinetics and not considered to be the target organs can be grouped together for ...
To increase internal exposure to parent compounds and metabolites in short term exposure studies, we therefore recommend careful consideration of zebrafish age in experimental design when these pharmacokinetic or toxicokinetic processes are of relevance to the research question. Based on our results with ...
provocation of pain. Larger initial doses were required to restore respiration in opioid overdoses. Notably, the effect of naloxone depends not only on the dose the opioid but also on the pharmacological characteristics of the opioid in question, as well as the constitution of the victim [4]....
An important question to consider is whether the effects of the drug relate to the peak or to average exposure of the drug. A relatively long dosing interval will require a rela- tively high Cmax to maintain an acceptable mean drug concentration or AUC. Therefore, in most in- stances, a ...
A key question related to the translational approach is which parameters have been most informed by the experimental data, and whether continuous learning can be achieved during the translational approach. The Kullback–Leibler divergence31 is a measure of relative entropy and was used to determine th...
The act of administering a medication may itself elicit a response (beneficial or adverse) that is unrelated to the pharmacodynamics of the drug in question but may be more related to psychologically induced effects. These effects are well described in humans, less so in veterinary practice...
There is a great deal of discrepancy between various reports on CYP alterations during HF, likely due to differences in disease severity, the species in question and other underlying conditions. A recent review by Aspromonte et al.217 has summarized a comprehensive modulation of cardiac CYP in ...